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Purine and pyrimidine phosphoribosyltransferases: A versatile tool for enzymatic synthesis of nucleoside-5′-monophosphates
(Current Pharmaceutical Design, 2017)
ackground: In recent years, enzymatic methods have shown to be an efficient and sustainable alternative for the synthesis of nucleosides and nucleoside-5′-monophosphates (NMPs) to the traditional multistep chemical methods, ...
One-pot multi-enzymatic production of purine derivatives with application in pharmaceutical and food industry
(Catalysts, 2018)
Biocatalysis reproduce nature’s synthetic strategies in order to synthesize different organic
compounds. Natural metabolic pathways usually involve complex networks to support cellular
growth and survival. In this regard, ...
Psychophysiological response and fine motor skills in high-altitude parachute jumps
(High Altitude Medicine and Biology, 2017-12-01)
We analyzed the psychophysiological response and specific fine motor skill of an experienced jumper in HALO (high altitude low opening) and HAHO (high altitude high opening) parachute jumps. Eight HALO and eight HAHO jumpers ...
Enzymatic Production Of Non-Natural Nucleoside-5′-Monophosphates By A Thermostable Uracil Phosphoribosyltransferase
(ChemCatChem, 2018-06-23)
The use of enzymes as biocatalysts applied to synthesis of modified nucleoside-5′-monophosphates (NMPs) is an interesting alternative to traditional multistep chemical methods which offers several advantages, such as ...
New trends for a classical enzyme: Papain, a biotechnological success story in the food industry
(2017-08-23)
Background In recent years, proteases have arisen as standard biocatalysts in many industrial processes in different fields, such as pharmaceutical, medicine, detergent manufacturing and food science. Among them, papain ...
Enzymatic production of dietary nucleotides from low-soluble purine bases by an efficient, thermostable and alkali-tolerant biocatalyst
(Food Chemistry, 2017-03-28)
Traditionally, enzymatic synthesis of nucleoside-5′-monophosphates (5′-NMPs) using low water-soluble purine bases has been described as less efficient due to their low solubility in aqueous media. The use of enzymes from ...
Effectiveness of psycho-physiological portable devices to analyse effect of ergogenic aids in military population
(Journal of Medical Systems, 2018-05-01)
Caffeine is one of the ergogenic substances most used by warfighters in current operation areas, but the effect on the organic response and operational performed is already poor knowledge. This research aimed to study the ...
One-pot, one-step production of dietary nucleotides by magnetic biocatalysts
(Catalysts, 2018-04-27)
The enzymatic synthesis of nucleotides offers several advantages over traditional multistep chemical methods, such as stereoselectivity, regioselectivity, enantioselectivity, simple downstream processing, and the use of ...
2′-Deoxyribosyltransferase from Leishmania mexicana, an efficient biocatalyst for one-pot, one-step synthesis of nucleosides from poorly soluble purine bases
(Applied Microbiology and Biotechnology, 2017)
Processes catalyzed by enzymes offer numerous advantages over chemical methods although in many occasions the stability of the biocatalysts becomes a serious concern. Traditionally, synthesis of nucleosides using poorly ...
Cloning, expression and biochemical characterization of xanthine and adenine phosphoribosyltransferases from thermus thermophilus Hb8
(Biocatalysis And Biotransformation, 2018-05-04)
Purine phosphoribosyltransferases, purine PRTs, are essential enzymes in the purine salvage pathway of living organisms. They are involved in the formation of C-N glycosidic bonds in purine nucleosides-5′-monophosphate ...