Show simple item record

dc.creatorGasparotto, Juciano
dc.creatorChaves Rodrigues, Paloma
dc.creatorDa Boit Martinello, Katia
dc.creatorDa Rosa Siva, Helen Tais
dc.creatorBortolin, Rafael Calixto
dc.creatorSilva Oliveira, Luis Felipe
dc.creatorRabelo, Thallita Kelly
dc.creatorDa Silva, Jeferson D
dc.creatorDa Silva, Fernanda Rabaioli
dc.creatorNordin, Adriane Perachi
dc.creatorSoares, Karina
dc.creatorBorges, Malu Siqueira
dc.creatorGelain, D. P
dc.creatorMoreira Fonseca, José Cláudio
dc.date.accessioned2018-11-13T22:16:30Z
dc.date.available2018-11-13T22:16:30Z
dc.date.issued2018-08-26
dc.identifier.issn01476513
dc.identifier.urihttp://hdl.handle.net/11323/919
dc.description.abstractObesity is an important nutritional disorder worldwide. Its association with environmental pollution may trigger an increase in oxidative stress and inflammatory parameters. Coal is a resource used throughout the world as an important fuel source for generating electricity. The ashes released by the coal combustion cause serious problems for human health due to their high toxicity and their capacity to bioaccumulate. The aim of this work was to investigate the effects of coal dust inhalation in the organs of obese and non-obese Wistar rats. Pro-inflammatory cytokines, oxidative stress, oxidative damage, histological analysis, comet assay, and micronuclei were investigated. Both obesity and coal dust inhalation increased the pro-inflammatory cytokines IL-1β and TNF-α and decreased HSP70 levels in serum, however, in obese animals that inhaled coal dust these changes were more pronounced. Liver histological analysis showed severe microvesicular steatosis in obese animals that inhaled coal dust. Lung histologic investigation showed abnormalities in lung structure of animals exposed to coal dust and showed severe lung distensibility in obese animals exposed to coal dust.es_CO
dc.language.isoengen_US
dc.publisherEcotoxicology And Environmental Safetyen_US
dc.relation.ispartofDOI: 10.1016/j.ecoenv.2018.08.097en_US
dc.rightsAtribución – No comercial – Compartir igualen_US
dc.subjectCoalen_US
dc.subjectInflammationen_US
dc.subjectInhalationen_US
dc.subjectObesityen_US
dc.subjectOxidative Stressen_US
dc.titleObese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese ratsen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record