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dc.contributor.authorEspitia Pérez, Pedrospa
dc.contributor.authorAlbino Marin, Suelenspa
dc.contributor.authorEspitia Pérez, Lydaspa
dc.contributor.authorBrango, Hugospa
dc.contributor.authorDa Rosa, Helen Taisspa
dc.contributor.authorKleber Silveira, Alexandrespa
dc.contributor.authorCerveira, Camilaspa
dc.contributor.authorMoraes Pompéu, Diogospa
dc.contributor.authorMingori Rodrigues, Moaraspa
dc.contributor.authorTiefensee Ribeiro, Camilaspa
dc.contributor.authorGelain, D. Pspa
dc.contributor.authorSchnorr, Carlos Eduardospa
dc.contributor.authorFonseca Moreira, José Claudiospa
dc.date.accessioned2018-11-14T01:11:14Z
dc.date.available2018-11-14T01:11:14Z
dc.date.issued2018-10-05
dc.identifier.issn0161813Xspa
dc.identifier.urihttp://hdl.handle.net/11323/933spa
dc.description.abstractFish consumption and ubiquitous methylmercury (MeHg) exposure represent a public health problem globally. Micronutrients presented in fish affects MeHg uptake/distribution. Vitamin A (VitA), another fish micronutrient is used in nutritional supplementation, especially during pregnancy. However, there is no information about the health effects arising from their combined exposure. The present study aimed to examine the effects of both MeHg and retinyl palmitate administered to pregnant and lactating rats. Thirty Wistar female rats were orally supplemented with MeHg (0,5 mg/Kg/day) and retinyl palmitate (7500 μg RAE1/Kg/day), either individually or in combination from the gestational day 0 to weaning. In dams, maternal behavior was scored. In neonatal and infant offspring, associative learning and neurodevelopment were evaluated. Further periadolescent male and female pups were assessed for open field, habituation and object recognition using episodic-like memory paradigm. Maternal and offspring redox parameters were evaluated. Our results showed no effects of MeHg-VitA co-administration in the quality of maternal care but showed subtle alterations in the pro-oxidant response of the hippocampus. In offspring, MeHg-VitA co-exposure affected early associative learning in neonatal pups, with no further modifications in neurodevelopment, and no locomotor or exploratory alterations in later developmental stages. Habituation was altered in a sex-dependent manner, but no overall memory disturbances were encountered.spa
dc.language.isoeng
dc.publisherDOI: 10.1016/j.neuro.2018.10.004spa
dc.rightsAtribución – No comercial – Compartir igualspa
dc.subjectBehavioreng
dc.subjectCo-Exposureeng
dc.subjectMethylmercuryeng
dc.subjectOxidative stresseng
dc.subjectPregnancyeng
dc.subjectRetinyl palmitateeng
dc.titleNeurobehavioral And Oxidative Stress Alterations Following Methylmercury And Retinyl Palmitate Co-Administration In Pregnant And Lactating Rats And Their Offspringeng
dc.typeArtículo de revistaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.identifier.instnameCorporación Universidad de la Costaspa
dc.identifier.reponameREDICUC - Repositorio CUCspa
dc.identifier.repourlhttps://repositorio.cuc.edu.co/spa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa


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