Itens para a visualização no momento 1-8 of 8

A color fusion model based on Markowitz portfolio optimization for optic disc segmentation in retinal images

Escorcia-Gutierrez, Jose; Torrents-Barrena, Jordina; Gamarra, Margarita; Romero-Aroca, Pedro; Valls, Aida; Puig, Domenec (Corporación Universidad de la Costa, 2021-07-15)

Retinal disorders are a severe health threat for older adults because they may lead to vision loss and blindness. Diabetic patients are particularly prone to suffer from Diabetic Retinopathy. Identifying relevant structural ...
Artificial intelligence with big data analytics-based brain intracranial hemorrhage e-diagnosis using CT images

Mansour, Romany F.; Escorcia-Gutierrez, Jose; Gamarra, Margarita; Garcia-Diaz, Vicente; Gupta, Deepak; kumar, sachin (Corporación Universidad de la Costa, 2021-06-21)

Due to the fast development of medical imaging technologies, medical image analysis has entered the period of big data for proper disease diagnosis. At the same time, intracerebral hemorrhage (ICH) becomes a serious disease ...
Convexity shape constraints for retinal blood vessel segmentation and foveal avascular zone detection

Escorcia-Gutierrez, Jose; Torrents-Barrena, Jordina; Gamarra, Margarita; Romero-Aroca, Pedro; Valls, Aida; Puig, Domenec (Corporación Universidad de la Costa, 2020)

Diabetic retinopathy (DR) has become a major worldwide health problem due to the increase in blindness among diabetics at early ages. The detection of DR pathologies such as microaneurysms, hemorrhages and exudates through ...
Diagnosis of leukemia disease based on enhanced virtual neural network

Muthumayil, K.; Manikandan, S.; Srinivasan, S.; Escorcia-Gutierrez, Jose; Gamarra, Margarita; Mansour, Romany F. (Corporación Universidad de la Costa, 2021)

White Blood Cell (WBC) cancer or leukemia is one of the serious cancers that threaten the existence of human beings. In spite of its prevalence and serious consequences, it is mostly diagnosed through manual practices. The ...
Identification of microbiota biomarkers with orthologous gene annotation for type 2 diabetes

Zhang, Yu-Hang; Guo, Wei; Tao, Zeng; ShiQi, Zhang; Chen, Lei; Gamarra, Margarita; Mansour, Romany F.; Escorcia-Gutierrez, Jose; Huang, Tao; Yu Dong, Cai (2021-07-09)

Type 2 diabetes (T2D) is a systematic chronic metabolic condition with abnormal sugar metabolism dysfunction, and its complications are the most harmful to human beings and may be life-threatening after long-term durations. ...
Investigating gene methylation signatures for fetal intolerance prediction

Zhang, Yu-Hang; Li, Zhandong; Zeng, Tao; Chen, Lei; Li, Hao; Gamarra, Margarita; MansourI, Romany F.; Escorcia-Gutierrez, Jose; Huang, Tao; Cai, Yu-Dong (Corporación Universidad de la Costa, 2021-04-22)

Pregnancy is a complicated and long procedure during one or more offspring development inside a woman. A short period of oxygen shortage after birth is quite normal for most babies and does not threaten their health. ...
MC-Kmeans: an approach to cell image segmentation using clustering algorithms

Gamarra, Margarita; Manjarres, Yesit; Torres Torres, Melitsa; Escorcia-Gutierrez, Jose; Zurek, Eduardo (Corporación Universidad de la Costa, 2021)

Digital image processing has been a fundamental tool for the diagnostic and treatment of diseases. Several techniques have been used to analyze microscopic images in cell-level processes. Different methods for the segmentation ...
Unsupervised deep learning based variational autoencoder model for COVID-19 diagnosis and classification

Mansour, Romany F.; Escorcia-Gutierrez, Jose; Gamarra, Margarita; Gupta, Deepak; Castillo, Oscar; kumar, sachin (Corporación Universidad de la Costa, 2021)

At present times, COVID-19 has become a global illness and infected people has increased exponentially and it is difficult to control due to the non-availability of large quantity of testing kits. Artificial intelligence ...

Envíos recientes

A color fusion model based on Markowitz portfolio optimization for optic disc segmentation in retinal images
...
Escorcia-Gutierrez, Jose | 2021-07-15

Retinal disorders are a severe health threat for older adults because they may lead to vision loss and blindness. Diabetic patients are particularly prone to suffer from Diabetic Retinopathy. Identifying relevant structural components in color fundus images like the optic disc (OD) is crucial to diagnose retinal diseases. Automatic OD detection is complex because of its location in an area where blood vessels converge, and color distribution is uneven. Several image processing techniques have been developed for OD detection so far, but vessel segmentation is sometimes required, increasing computational complexity and time. Moreover, precise OD segmentation methods utilize complex algorithms that need special hardware or extensive labeled datasets. We propose an OD detection approach based on the Modern Portfolio Theory of Markowitz to generate an innovative color fusion model. Specifically, the training phase calculates the optimal weights for each color channel. A fusion of weighted color channels is then applied in the testing phase. This approach acts as a powerful and real-time preprocessing stage. We use four heterogeneous datasets to validate the presented methodology. Three out of four datasets are publicly available (i.e., DRIVE, Messidor, and HRF), and the last corresponds to an in–house dataset acquired from Hospital Universitari Sant Joan de Reus (Spain). Two different segmentation methods are presented and compared with state-of-the-art computer vision techniques to analyze the model performance. An outstanding accuracy and overlap above 0.9 and 80%, respectively, and a minimal execution time of 0.05 s are reached. Therefore, our model could be integrated into daily clinical practice to accelerate the diagnosis of Diabetic Retinopathy due to its simplicity, performance, and speed.

LEER
Artificial intelligence with big data analytics-based brain intracranial hemorrhage e-diagnosis using CT images
...
Mansour, Romany F. | 2021-06-21

Due to the fast development of medical imaging technologies, medical image analysis has entered the period of big data for proper disease diagnosis. At the same time, intracerebral hemorrhage (ICH) becomes a serious disease which affects the injury of blood vessels in the brain regions. This paper presents an artificial intelligence and big data analytics-based ICH e-diagnosis (AIBDA-ICH) model using CT images. The presented model utilizes IoMT devices for data acquisition process. The presented AIBDA-ICH model involves graph cut-based segmentation model for identifying the affected regions in the CT images. To manage big data, Hadoop Ecosystem and its elements are mainly used. In addition, capsule network (CapsNet) model is applied as a feature extractor to derive a useful set of feature vectors. Finally, the presented AIBDA-ICH model makes use of the fuzzy deep neural network (FDNN) model to carry out classification process. For validating the superior performance of the AIBDA-ICH method, an extensive set of simulations were performed and the outcomes are examined under diverse aspects. The experimental values pointed out the improved e-diagnostic performance of the AIBDA-ICH model over the other compared methods with the precision and accuracy of 94.96% and 98.59%, respectively.

LEER
Convexity shape constraints for retinal blood vessel segmentation and foveal avascular zone detection
...
Escorcia-Gutierrez, Jose | 2020

Diabetic retinopathy (DR) has become a major worldwide health problem due to the increase in blindness among diabetics at early ages. The detection of DR pathologies such as microaneurysms, hemorrhages and exudates through advanced computational techniques is of utmost importance in patient health care. New computer vision techniques are needed to improve upon traditional screening of color fundus images. The segmentation of the entire anatomical structure of the retina is a crucial phase in detecting these pathologies. This work proposes a novel framework for fast and fully automatic blood vessel segmentation and fovea detection. The preprocessing method involved both contrast limited adaptive histogram equalization and the brightness preserving dynamic fuzzy histogram equalization algorithms to enhance image contrast and eliminate noise artifacts. Afterwards, the color spaces and their intrinsic components were examined to identify the most suitable color model to reveal the foreground pixels against the entire background. Several samples were then collected and used by the renowned convexity shape prior segmentation algorithm. The proposed methodology achieved an average vasculature segmentation accuracy exceeding 96%, 95%, 98% and 94% for the DRIVE, STARE, HRF and Messidor publicly available datasets, respectively. An additional validation step reached an average accuracy of 94.30% using an in-house dataset provided by the Hospital Sant Joan of Reus (Spain). Moreover, an outstanding detection accuracy of over 98% was achieved for the foveal avascular zone. An extensive state-of-the-art comparison was also conducted. The proposed approach can thus be integrated into daily clinical practice to assist medical experts in the diagnosis of DR.

LEER
Diagnosis of leukemia disease based on enhanced virtual neural network
...
Muthumayil, K. | 2021

White Blood Cell (WBC) cancer or leukemia is one of the serious cancers that threaten the existence of human beings. In spite of its prevalence and serious consequences, it is mostly diagnosed through manual practices. The risks of inappropriate, sub-standard and wrong or biased diagnosis are high in manual methods. So, there is a need exists for automatic diagnosis and classification method that can replace the manual process. Leukemia is mainly classified into acute and chronic types. The current research work proposed a computer-based application to classify the disease. In the feature extraction stage, we use excellent physical properties to improve the diagnostic system’s accuracy, based on Enhanced Color Co-Occurrence Matrix. The study is aimed at identification and classification of chronic lymphocytic leukemia using microscopic images of WBCs based on Enhanced Virtual Neural Network (EVNN) classification. The proposed method achieved optimum accuracy in detection and classification of leukemia from WBC images. Thus, the study results establish the superiority of the proposed method in automated diagnosis of leukemia. The values achieved by the proposed method in terms of sensitivity, specificity, accuracy, and error rate were 97.8%, 89.9%, 76.6%, and 2.2%, respectively. Furthermore, the system could predict the disease in prior through images, and the probabilities of disease detection are also highly optimistic.

LEER
Identification of microbiota biomarkers with orthologous gene annotation for type 2 diabetes
...
Zhang, Yu-Hang | 2021-07-09

Type 2 diabetes (T2D) is a systematic chronic metabolic condition with abnormal sugar metabolism dysfunction, and its complications are the most harmful to human beings and may be life-threatening after long-term durations. Considering the high incidence and severity at late stage, researchers have been focusing on the identification of specific biomarkers and potential drug targets for T2D at the genomic, epigenomic, and transcriptomic levels. Microbes participate in the pathogenesis of multiple metabolic diseases including diabetes. However, the related studies are still non-systematic and lack the functional exploration on identified microbes. To fill this gap between gut microbiome and diabetes study, we first introduced eggNOG database and KEGG ORTHOLOGY (KO) database for orthologous (protein/gene) annotation of microbiota. Two datasets with these annotations were employed, which were analyzed by multiple machine-learning models for identifying significant microbiota biomarkers of T2D. The powerful feature selection method, Max-Relevance and Min-Redundancy (mRMR), was first applied to the datasets, resulting in a feature list for each dataset. Then, the list was fed into the incremental feature selection (IFS), incorporating support vector machine (SVM) as the classification algorithm, to extract essential annotations and build efficient classifiers. This study not only revealed potential pathological factors for diabetes at the microbiome level but also provided us new candidates for drug development against diabetes.

LEER
Investigating gene methylation signatures for fetal intolerance prediction
...
Zhang, Yu-Hang | 2021-04-22

Pregnancy is a complicated and long procedure during one or more offspring development inside a woman. A short period of oxygen shortage after birth is quite normal for most babies and does not threaten their health. However, if babies have to suffer from a long period of oxygen shortage, then this condition is an indication of pathological fetal intolerance, which probably causes their death. The identification of the pathological fetal intolerance from the physical oxygen shortage is one of the important clinical problems in obstetrics for a long time. The clinical syndromes typically manifest five symptoms that indicate that the baby may suffer from fetal intolerance. At present, liquid biopsy combined with high-throughput sequencing or mass spectrum techniques provides a quick approach to detect real-time alteration in the peripheral blood at multiple levels with the rapid development of molecule sequencing technologies. Gene methylation is functionally correlated with gene expression; thus, the combination of gene methylation and expression information would help in screening out the key regulators for the pathogenesis of fetal intolerance. We combined gene methylation and expression features together and screened out the optimal features, including gene expression or methylation signatures, for fetal intolerance prediction for the first time. In addition, we applied various computational methods to construct a comprehensive computational pipeline to identify the potential biomarkers for fetal intolerance dependent on the liquid biopsy samples. We set up qualitative and quantitative computational models for the prediction for fetal intolerance during pregnancy. Moreover, we provided a new prospective for the detailed pathological mechanism of fetal intolerance. This work can provide a solid foundation for further experimental research and contribute to the application of liquid biopsy in antenatal care.

LEER
MC-Kmeans: an approach to cell image segmentation using clustering algorithms
...
Gamarra, Margarita | 2021

Digital image processing has been a fundamental tool for the diagnostic and treatment of diseases. Several techniques have been used to analyze microscopic images in cell-level processes. Different methods for the segmentation task are recognized for its contribution in the image processing. Nevertheless, not all are useful in the studies at a microscopic level. In most of the biomedical images, cells are visually clustered and this makes that, simple and fast algorithms which are used in the other cases, may fail. This research proposes the development of a segmentation algorithm in HEp-2 cells type, using the marker-controlled watershed and k-means methods. This approach achieves an improvement in the cell segmentation, which allows obtaining effective information in the posterior analysis. We obtained a precision of 82.3% in the performance and in the qualitative analysis the method reached an outstanding performance in comparison with the other segmentation techniques used in the experiments. Finally, we concluded that the algorithm proposed, is suitable for the segmentation of the studied cells.

LEER
Unsupervised deep learning based variational autoencoder model for COVID-19 diagnosis and classification
...
Mansour, Romany F. | 2021

At present times, COVID-19 has become a global illness and infected people has increased exponentially and it is difficult to control due to the non-availability of large quantity of testing kits. Artificial intelligence (AI) techniques including machine learning (ML), deep learning (DL), and computer vision (CV) approaches find useful for the recognition, analysis, and prediction of COVID-19. Several ML and DL techniques are trained to resolve the supervised learning issue. At the same time, the potential measure of the unsupervised learning technique is quite high. Therefore, unsupervised learning techniques can be designed in the existing DL models for proficient COVID-19 prediction. In this view, this paper introduces a novel unsupervised DL based variational autoencoder (UDL-VAE) model for COVID-19 detection and classification. The UDL-VAE model involved adaptive Wiener filtering (AWF) based preprocessing technique to enhance the image quality. Besides, Inception v4 with Adagrad technique is employed as a feature extractor and unsupervised VAE model is applied for the classification process. In order to verify the superior diagnostic performance of the UDL-VAE model, a set of experimentation was carried out to highlight the effective outcome of the UDL-VAE model. The obtained experimental values showcased the effectual results of the UDL-VAE model with the higher accuracy of 0.987 and 0.992 on the binary and multiple classes respectively.

LEER

Navegação por autor "Escorcia-Gutierrez, Jose"

A color fusion model based on Markowitz portfolio optimization for optic disc segmentation in retinal images ﻿

Artificial intelligence with big data analytics-based brain intracranial hemorrhage e-diagnosis using CT images ﻿

Convexity shape constraints for retinal blood vessel segmentation and foveal avascular zone detection ﻿

Diagnosis of leukemia disease based on enhanced virtual neural network ﻿

Identification of microbiota biomarkers with orthologous gene annotation for type 2 diabetes ﻿

Investigating gene methylation signatures for fetal intolerance prediction ﻿

MC-Kmeans: an approach to cell image segmentation using clustering algorithms ﻿

Unsupervised deep learning based variational autoencoder model for COVID-19 diagnosis and classification ﻿

Envíos recientes

A color fusion model based on Markowitz portfolio optimization for optic disc segmentation in retinal images

Artificial intelligence with big data analytics-based brain intracranial hemorrhage e-diagnosis using CT images

Convexity shape constraints for retinal blood vessel segmentation and foveal avascular zone detection

Diagnosis of leukemia disease based on enhanced virtual neural network

Identification of microbiota biomarkers with orthologous gene annotation for type 2 diabetes

Investigating gene methylation signatures for fetal intolerance prediction

MC-Kmeans: an approach to cell image segmentation using clustering algorithms

Unsupervised deep learning based variational autoencoder model for COVID-19 diagnosis and classification

A color fusion model based on Markowitz portfolio optimization for optic disc segmentation in retinal images

Artificial intelligence with big data analytics-based brain intracranial hemorrhage e-diagnosis using CT images

Convexity shape constraints for retinal blood vessel segmentation and foveal avascular zone detection

Diagnosis of leukemia disease based on enhanced virtual neural network

Identification of microbiota biomarkers with orthologous gene annotation for type 2 diabetes

Investigating gene methylation signatures for fetal intolerance prediction

MC-Kmeans: an approach to cell image segmentation using clustering algorithms

Unsupervised deep learning based variational autoencoder model for COVID-19 diagnosis and classification