Navegação por autor "Fernandez Lucas, Jesus"
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2′-Deoxyribosyltransferase from Leishmania mexicana, an efficient biocatalyst for one-pot, one-step synthesis of nucleosides from poorly soluble purine bases
Crespo, N.; Sánchez Murcia, Pedro Alejandro; Gago, Federico; Cejudo Sanches, J.; Galmes, M.A.; Fernandez Lucas, Jesus; Mancheño, José Miguel (Applied Microbiology and Biotechnology, 2017)Processes catalyzed by enzymes offer numerous advantages over chemical methods although in many occasions the stability of the biocatalysts becomes a serious concern. Traditionally, synthesis of nucleosides using poorly ... -
Characterization Of An Atypical, Thermostable, Organic Solvent- And Acid-Tolerant 2′-Deoxyribosyltransferase From Chroococcidiopsis Thermalis
Del Arco, Jon; Sánchez Murcia, Pedro Alejandro; Mancheño José Miguel, José Miguel; Gago, Federico; Fernandez Lucas, Jesus (Applied Microbiology And Biotechnology, 2018-05-23)In our search for thermophilic and acid-tolerant nucleoside 2′-deoxyribosyltransferases (NDTs), we found a good candidate in an enzyme encoded by Chroococcidiopsis thermalis PCC 7203 (CtNDT). Biophysical and biochemical ... -
Cloning, expression and biochemical characterization of xanthine and adenine phosphoribosyltransferases from thermus thermophilus Hb8
Del Arco, Jon; Martinez, María; Donday, Manuel; Clemente Suárez, Vicente Javier; Fernandez Lucas, Jesus (Biocatalysis And Biotransformation, 2018-05-04)Purine phosphoribosyltransferases, purine PRTs, are essential enzymes in the purine salvage pathway of living organisms. They are involved in the formation of C-N glycosidic bonds in purine nucleosides-5′-monophosphate ... -
Effectiveness of psycho-physiological portable devices to analyse effect of ergogenic aids in military population
Diaz Manzano, Montaña; Robles Perez, Jose Juan; Herrera Mendoza, Ketty Milena; Herrera Tapias, Belina Annery; Fernandez Lucas, Jesus; Aznar Lain, Susana; Clemente Suárez, Vicente Javier (Journal of Medical Systems, 2018-05-01)Caffeine is one of the ergogenic substances most used by warfighters in current operation areas, but the effect on the organic response and operational performed is already poor knowledge. This research aimed to study the ... -
Enzymatic production of dietary nucleotides from low-soluble purine bases by an efficient, thermostable and alkali-tolerant biocatalyst
Del Arco, Jon; Cejudo Sanches, J.; Esteban, I; Clemente Suárez, Vicente Javier; Hormigo, Daniel; Perona, Almudena; Fernandez Lucas, Jesus (Food Chemistry, 2017-03-28)Traditionally, enzymatic synthesis of nucleoside-5′-monophosphates (5′-NMPs) using low water-soluble purine bases has been described as less efficient due to their low solubility in aqueous media. The use of enzymes from ... -
Enzymatic Production Of Non-Natural Nucleoside-5′-Monophosphates By A Thermostable Uracil Phosphoribosyltransferase
Del Arco, Jon; Acosta, Javier; D'Muniz Pereira, Humberto; Perona, Almudena; Lokanath, Neratur Krishnappagowda; Kunishima, Naoki; Fernandez Lucas, Jesus (ChemCatChem, 2018-06-23)The use of enzymes as biocatalysts applied to synthesis of modified nucleoside-5′-monophosphates (NMPs) is an interesting alternative to traditional multistep chemical methods which offers several advantages, such as ... -
Enzymatic Synthesis Of Therapeutic Nucleosides Using A Highly Versatile Purine Nucleoside 2’-Deoxyribosyltransferase From Trypanosoma Brucei
Pérez, Elena; Sánchez Murcia, Pedro Alejandro; Jordaan, Justin; Blanco, María Dolores; Mancheño, José Miguel; Gago, Federico; Fernandez Lucas, Jesus (ChemCatChem, 2018-07-18)The use of enzymes for the synthesis of nucleoside analogues offers several advantages over multistep chemical methods, including chemo-, regio- and stereoselectivity as well as milder reaction conditions. Herein, the ... -
New trends for a classical enzyme: Papain, a biotechnological success story in the food industry
Fernandez Lucas, Jesus; Castañeda Valbuena, Daniel; Hormigo, Daniel (2017-08-23)Background In recent years, proteases have arisen as standard biocatalysts in many industrial processes in different fields, such as pharmaceutical, medicine, detergent manufacturing and food science. Among them, papain ... -
One-pot multi-enzymatic production of purine derivatives with application in pharmaceutical and food industry
Acosta, Javier; Del Arco, Jon; Martínez Pascual, Sara; Clemente Suárez, Vicente Javier; Fernandez Lucas, Jesus (Catalysts, 2018)Biocatalysis reproduce nature’s synthetic strategies in order to synthesize different organic compounds. Natural metabolic pathways usually involve complex networks to support cellular growth and survival. In this regard, ... -
One-pot, one-step production of dietary nucleotides by magnetic biocatalysts
Del Arco, Jon; Martínez Pascual, Sara; Clemente Suárez, Vicente Javier; Corral Pazos de Provens, Octavio Jorge; Jordaan, Justin; Hormigo, Daniel; Perona, Almudena; Fernandez Lucas, Jesus (Catalysts, 2018-04-27)The enzymatic synthesis of nucleotides offers several advantages over traditional multistep chemical methods, such as stereoselectivity, regioselectivity, enantioselectivity, simple downstream processing, and the use of ... -
Psychophysiological response and fine motor skills in high-altitude parachute jumps
Clemente Suárez, Vicente Javier; Robles Pérez, José Juan; Herrera Mendoza, Ketty Milena; Herrera Tapias, Belina Annery; Fernandez Lucas, Jesus (High Altitude Medicine and Biology, 2017-12-01)We analyzed the psychophysiological response and specific fine motor skill of an experienced jumper in HALO (high altitude low opening) and HAHO (high altitude high opening) parachute jumps. Eight HALO and eight HAHO jumpers ... -
Purine and pyrimidine phosphoribosyltransferases: A versatile tool for enzymatic synthesis of nucleoside-5′-monophosphates
Del Arco, Jon; Fernandez Lucas, Jesus (Current Pharmaceutical Design, 2017)ackground: In recent years, enzymatic methods have shown to be an efficient and sustainable alternative for the synthesis of nucleosides and nucleoside-5′-monophosphates (NMPs) to the traditional multistep chemical methods, ... -
Purine And Pyrimidine Salvage Pathway In Thermophiles: A Valuable Source Of Biocatalysts For The Industrial Production Of Nucleic Acid Derivatives
Del Arco, Jon; Fernandez Lucas, Jesus (Applied Microbiology And Biotechnology, 2018-07-11)Due to their similarity to natural counterparts, nucleic acid derivatives (nucleobases, nucleosides, and nucleotides, among others) are interesting molecules for pharmaceutical, biomedical, or food industries. For this ...