Now showing items 1-15 of 15

    • A new animal diet based on human western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption 

      Calixto Bortolin, Rafael; Rodrigues Vargas, Amanda; Gasparotto, Juciano; Rodrigues Chaves, Paloma; Schnorr, Carlos Eduardo; Da Boit Martinello, Katia; Kleber Silveira, Alexandre; Rabelo, Thallita Kelly; Gelain, D. P; Moreira Fonseca, Jose Claudio (Universidad de la Costa, 2018)
      Background/Objectives:Obesity is a metabolic disorder that predisposes patients to numerous diseases and has become a major global public-health concern. Animal models of diet-induced obesity (DIO) are frequently used to ...
    • A review on the environmental impact of phosphogypsum and potential health impacts through the release of nanoparticles 

      Silva Oliveira, Luis Felipe; Silva Oliveira, Marcos Leandro; Crissien Borrero, Tito José; Santosh, M.; Bolivar, Juan; Shao, Longyi; Dotto, Guilherme Luiz; Gasparotto, Juciano; Schindleri, Michael (Corporación Universidad de la Costa, 2021-07-09)
      Many industrial by-products have been disposed along coastlines, generating profound marine changes. Phosphogypsum (PG) is a solid by-product generated in the production of phosphoric acid (PA) using conventional synthesis ...
    • BRCA-1 depletion impairs pro-inflammatory polarization and activation of RAW 264.7 macrophages in a NF-κB-dependent mechanism 

      da Silva Morrone, Maurilio; Somensi, Nauana; Franz, Lucas; de Miranda Ramos, Vitor; Gasparotto, Juciano; Taís da Rosa, Helen; Sartori, Marcelo; Figueiró, Fabrício; Gelain, Daniel; ZANOTTO-FILHO, ALFEU; Moreira, José Cláudio Fonseca (Universidad de la Costa, 2019-12)
      BRCA-1 is a nuclear protein involved in DNA repair, transcriptional regulation, and cell cycle control. Its involvement in other cellular processes has been described. Here, we aimed to investigate the role of BRCA-1 in ...
    • Characterization and modulation of microglial phenotypes in an animal model of severe sepsis 

      Michels, Monique; Rocha Abatti, Mariane; Avila, Pricila; Vieira, Andriele; Borges, Heloisa; Carvalho Junior, Celso; Wendhausen, Diogo; Gasparotto, Juciano; Tiefensee Ribeiro, Camila; Moreira, José Cláudio Fonseca; Pens Gelain, Daniel; Dal‐Pizzol, Felipe (Journal of Cellular and Molecular Medicine, 2019-10-26)
      We aim to characterize the kinetics of early and late microglial phenotypes after systemic inflammation in an animal model of severe sepsis and the effects of minocycline on these phenotypes. Rats were subjected to CLP, ...
    • Guarana supplementation attenuated obesity, insulin resistance, and adipokines dysregulation induced by a standardized human Western diet via brown adipose tissue activation 

      Calixto Bortolin, Rafael; Rodrigues Vargas, Amanda; de Miranda Ramos, Vitor; Gasparotto, Juciano; Rodrigues Chaves, Paloma; Schnorr, Carlos Eduardo; da Boit Martinello, Katia; Kleber Silveira, Alexandre; Mautone Gomes, Henrique; Kelly Rabelo, Thallita; Sartori Grunwald, Marcelo; Ligabue‐Braun, Rodrigo; Pens Gelain, Daniel; Fonseca Moreira, José Claudio (Universidad de la Costa, 2019-02-09)
      Obesity is a metabolic disorder associated with adverse health consequences that has increased worldwide at an epidemic rate. This has encouraged many people to utilize nonprescription herbal supplements for weight loss ...
    • High fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation and oxidative stress 

      Bittencourt, Aline; Ozorio Brum, Pedro; Tiefensee Ribeiro, Camila; Gasparotto, Juciano; Bortolin, Rafael Calixto; Rodrigues de Vargas, Amanda; Heimfarth, Luana; Farina de Almeida, Roberto; Moreira, José Cláudio Fonseca; de Oliveira, Jade; Pens Gelain, Daniel (Corporación Universidad de la Costa, 2020-10-20)
      Obesity is a health problem that has been associated with neuroinflammation, decreased cognitive functions and development of neurodegenerative diseases. Parkinson’s disease (PD) is a chronic neurodegenerative condition ...
    • Nanoparticles in fossil and mineral fuel sectors and their impact on environment and human health: A review and perspective 

      Silva Oliveira, Luis Felipe; Santosh, M; Schindler, Michael; Gasparotto, Juciano; Dotto, Guilherme Luiz; S. Oliveira, Marcos L.; Hochella, Jr. (Corporación Universidad de la Costa, 2021)
      Nanoscience and technology have enabled better insights into the environmental and health impacts arising from the mining, production and use of fossil and mineral fuels. Here we provide an overview of the nanoscience-based ...
    • Obese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese rats 

      Gasparotto, Juciano; Chaves Rodrigues, Paloma; Da Boit Martinello, Katia; Da Rosa Siva, Helen Tais; Bortolin, Rafael Calixto; Silva Oliveira, Luis Felipe; Rabelo, Thallita Kelly; Da Silva, Jeferson D; Da Silva, Fernanda Rabaioli; Nordin, Adriane Perachi; Soares, Karina; Borges, Malu Siqueira; Gelain, D. P; Moreira Fonseca, José Cláudio (Ecotoxicology And Environmental Safety, 2018-08-26)
      Obesity is an important nutritional disorder worldwide. Its association with environmental pollution may trigger an increase in oxidative stress and inflammatory parameters. Coal is a resource used throughout the world as ...
    • Obesity associated with coal ash inhalation triggers systemic inflammation and oxidative damage in the hippocampus of rats 

      Gasparotto, Juciano; Rodrigues Chaves, Paloma; Boit Martinello, Katiada; Silva Oliveira, Luis Felipe; Pens Gelain, Daniel; Fonseca Moreira, José Claudio (Universidad de la Costa, 2019)
      People with large amounts of adipose tissue are more vulnerable and more likely to develop diseases where oxidative stress and inflammation play a pivotal role, than persons with a healthy weight. Atmospheric contamination ...
    • Oral administration of carvacrol/β-cyclodextrin complex protects against 6-hydroxydopamine-induced dopaminergic denervation 

      Tiefensee Ribeiro, Camila; Gasparotto, Juciano; Lintzmaier Petiz, Lyvia; Ozorio Brum, Pedro; Oppermann Peixoto, Daniel; Kunzler, Alice; Tais da Rosa Silva, Helen; Calixto Bortolin, Rafael; Farina Almeida, Roberto; Quintans-Junior, Lucindo José; Antunes Araújo, Adriano; Fonseca Moreira, José Claudio; Pens Gelain, Daniel (Universidad de la Costa, 2019-02-28)
      Carvacrol (CARV) presents valuable biological properties such as anti-inflammatory and antioxidant activities. However, pharmacological uses of CARV are largely limited due to disadvantages related to solubility, ...
    • Oxidative stress biomarkers as prognostic indicators of severity in patients with dengue 

      Gasparotto, Juciano; Figueiró, Fabrício; de Fraga Dias, Amanda; Rostirolla, Diana Carolina; Somensi, Nauana; Taisda Rosa, Helen; Kich Grun, Lucas; Barbé Tuana, Florencia María; de Miranda Ramos, Vitor; Pens Gelain, Daniel; Fonseca Moreira, José Cláudio; Castro-Orozco, Raimundo; Marcelo, Adolfo; Garcia, María Paquita; Merino, Nancy; Escalante-Maldonado, Oscar; Mora, Cinthya; Rodriguez, Marlon; Alvis-Guzman, Nelson (Global Journal of Health Science, 2018-11-08)
      There is evidence for the role of oxidative stress in severe dengue pathogenesis. However, previous observational studies presents certain methodological limitations, which may affect its internal and external validity. ...
    • Retinoic acid downregulates thiol antioxidant defences and homologous recombination while promotes A549 cells sensitization to cisplatin 

      Gasparotto, Juciano; Figueiró, Fabrício; de Fraga Dias, Amanda; Rostirolla, Diana Carolina; Somensi, Nauana; Taisda Rosa, Helen; Kich Grun, Lucas; Barbé Tuana, Florencia María (Universidad de la Costa, 2019-10)
      Recent studies have investigated the use of retinoic acid (RA) molecule in combined chemotherapies to cancer cells as an attempt to increase treatment efficiency and circumvent cell resistance. Positive results were obtained ...
    • Systemic Inflammation Changes the Site of RAGE Expression from Endothelial Cells to Neurons in Different Brain Areas 

      Gasparotto, Juciano; Ribeiro Tiefensee, Camila; Da Rosa Siva, Helen Tais; Bortolin, Rafael Calixto; Rabelo, Thallita Kelly; Peixoto, Daniel Oppermann; Moreira Fonseca, José Cláudio; Gelain, D. P. (Molecular Neurobiology, 2019)
      The receptor for advanced glycation endproducts (RAGE) is a transmembrane, immunoglobulin-like receptor that interacts with a broad repertoire of extracellular ligands. RAGE belongs to a family of cell adhesion molecules ...
    • The effects of retinol oral supplementation in 6-hydroxydopamine dopaminergic denervation model in Wistar rats 

      Kunzler, Alice; Tiefensee Ribeiro, Camila; Gasparotto, Juciano; Lintzmaier Petiz, Lyvia; Thais da Rosa Silva, Helen; da Silva Jr., Jeferson Delgado; Bortolin, Rafael; Oliveira de Souza, Priscila; Barreto, Fabiano; Espitia-Perez, Pedro; Schnorr, Carlos Eduardo; Somensi, Nauana; Fonseca Moreira, José Claudio; Pens Gelain, Daniel (Universidad de la Costa, 2019-02-07)
      Vitamin A (retinol) is involved in signaling pathways regulating gene expression and was postulated to be a major antioxidant and anti-inflammatory compound of the diet. Parkinson's disease (PD) is a progressive ...
    • Workshop redacción científica 

      Universidad de la Costa; Gasparotto, Juciano (Universidad de la Costa, 2020-02-05)
      El Departamento de Ingeniería Civil y Ambiental de la Universidad de la Costa, con el fin de fortalecer los procesos académicos, realizó un “Workshop de redacción científica”', dirigido a profesores y estudiantes interesados ...