Now showing items 1-6 of 6

    • BRCA-1 depletion impairs pro-inflammatory polarization and activation of RAW 264.7 macrophages in a NF-κB-dependent mechanism 

      da Silva Morrone, Maurilio; Somensi, Nauana; Franz, Lucas; de Miranda Ramos, Vitor; Gasparotto, Juciano; Taís da Rosa, Helen; Sartori, Marcelo; Figueiró, Fabrício; Gelain, Daniel; ZANOTTO-FILHO, ALFEU; Moreira, José Cláudio Fonseca (Universidad de la Costa, 2019-12)
      BRCA-1 is a nuclear protein involved in DNA repair, transcriptional regulation, and cell cycle control. Its involvement in other cellular processes has been described. Here, we aimed to investigate the role of BRCA-1 in ...
    • Characterization and modulation of microglial phenotypes in an animal model of severe sepsis 

      Michels, Monique; Rocha Abatti, Mariane; Avila, Pricila; Vieira, Andriele; Borges, Heloisa; Carvalho Junior, Celso; Wendhausen, Diogo; Gasparotto, Juciano; Tiefensee Ribeiro, Camila; Moreira, José Cláudio Fonseca; Pens Gelain, Daniel; Dal‐Pizzol, Felipe (Journal of Cellular and Molecular Medicine, 2019-10-26)
      We aim to characterize the kinetics of early and late microglial phenotypes after systemic inflammation in an animal model of severe sepsis and the effects of minocycline on these phenotypes. Rats were subjected to CLP, ...
    • Chronic acrolein exposure in wistar rats: the effects of guarana extracts 

      da Silva Bittencourt, Leonardo; Schnorr, Carlos Eduardo; Copetti Santos, Daniela; Rostirolla, Diana Carolina; Moresco, Karla; Ozório, Pedro; Rodrigues Mingori, Moara; Heinfarth, Luana; Gelain, Daniel; Moreira, José Cláudio Fonseca (Corporación Universidad de la Costa, 2019-12-04)
      Previous studies have reported that acrolein, may exert harmful effects on the brain. However, information regarding the neuroprotective properties of guarana against acrolein is not available. Due to the lack of research, ...
    • Hepatic and neurobiological effects of foetal and breastfeeding and adulthood exposure to methylmercury in Wistar rats 

      da Rosa-Silva, Helen Tais; Castro Panzenhagen, Alana; Schmidtt, Victória; Alves Teixeira, Alexsander; Espitia-Pérez, Pedro Juan; de Oliveira Franco, Álvaro; Mingori, Moara; Torres-Ávila, José F.; Schnorr, Carlos Eduardo; Silva Hermann, Paolla Rissi; Pompéu Moraes, Diogo; Farina Almeida, Roberto; Moreira, José Cláudio Fonseca (Universidad de la Costa, 2020)
      Methylmercury (MeHg) is an organic bioaccumulated mercury derivative that strongly affects the environment and represents a public health problem primarily to riparian communities in South America. Our objective was to ...
    • High fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation and oxidative stress 

      Bittencourt, Aline; Ozorio Brum, Pedro; Tiefensee Ribeiro, Camila; Gasparotto, Juciano; Bortolin, Rafael Calixto; Rodrigues de Vargas, Amanda; Heimfarth, Luana; Farina de Almeida, Roberto; Moreira, José Cláudio Fonseca; de Oliveira, Jade; Pens Gelain, Daniel (Corporación Universidad de la Costa, 2020-10-20)
      Obesity is a health problem that has been associated with neuroinflammation, decreased cognitive functions and development of neurodegenerative diseases. Parkinson’s disease (PD) is a chronic neurodegenerative condition ...
    • Incidence of lung cancer and mortality among civil construction industry workers: A protocol for a systematic review and meta-analysis 

      Cahuana Pinto, Rita; Castro Panzenhagen, Alana; Silva Oliveira, Luis Felipe; Moreira, José Cláudio Fonseca; Schnorr, Carlos Eduardo (Corporación Universidad de la Costa, 2021-04-26)
      The construction sector is one of the most stable growth industries in the world. However, many studies have suggested an association between occupational exposure in civil construction and lung cancer risk. Thus, this ...