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The burden of carbohydrates in health and disease

Clemente-Suárez, Vicente Javier; Mielgo Ayuso, Juan; MARTIN-RODRIGUEZ, ALEXANDRA; Ramos-Campo, Domingo Jesús; REDONDO FLÓREZ, LAURA; Tornero Aguilera, José Francisco (Multidisciplinary Digital Publishing Institute (MDPI)Switzerland, 2022-09-15)

Foods high in carbohydrates are an important part of a healthy diet, since they provide the body with glucose to support bodily functions and physical activity. However, the abusive consumption of refined, simple, and ...
Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019

Kocarnik, Jonathan; Compton, Kelly; Dean, Frances E; Fu, Weijia; Gaw, Brian L; Harvey, James D; Henrikson, Hannah; Lu, Dan; Pennini, Alyssa; Xu, Rixing; Alvis-Guzmán, Nelson; Et al (American Medical AssociationUnited States, 2022)

Importance The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing ...
Environmental and human health risks associated with exposure to hazardous elements present in urban dust from Barranquilla, Colombian Caribbean

Osorio‐Martinez, Jorge; Silva Oliveira, Luis Felipe; Flores, Erico; Nascimento, Mariele S.; Picoloto, Rochele; Olivero-Verbel, Jesus (Corporación Universidad de la Costa, 2021-01-22)

Urban dust is a mixture of deposited particles from different sources usually linked to potentially toxic elements (PTEs). Despite the industrialization of many South American countries, little is known about the impact ...
Evaluación del cumplimiento de la resolución 1441 de 2013 en el Instituto Oncohematologico Biobetania de la Ciudad de Barranquilla

Olivares Flórez, Arelys (Especialización en Gestión de la Calidad y Auditoría en Servicios de Salud, 2014-03-10)

Treatments for such sensitive diseases such as cancer can not be subject to procedures that do not guarantee the quality of them, being the way that is necessary assessment processes in regard to medical processes. Therefore, ...
The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019

Bao Tran, Khanh; Lang, Justin J; Compton, Kelly; Xu, Rixing; Acheson, Alistair R; Henrikson, Hannah Jacqueline; Kocarnik, Jonathan M; Penberthy, Louise; Aali, Amirali; Abbas, Qamar (Elsevier Ltd.United Kingdom, 2022-08)

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global ...
Nutritional and exercise interventions in cancer-related cachexia: an extensive narrative review

Clemente-Suárez, Vicente Javier; Redondo-Flórez, Laura; Rubio-Zarapuz, Alejandro; Martínez-Guardado, Ismael; Navarro-Jiménez, Eduardo; Tornero-Aguilera, José Francisco (Multidisciplinary Digital Publishing Institute (MDPI)Switzerland, 2022-04-11)

One of the common traits found in cancer patients is malnutrition and cachexia, which affects between 25% to 60% of the patients, depending on the type of cancer, diagnosis, and treatment. Given the lack of current effective ...
Trends in cancer mortality in Colombia, 1979-2019

ALVIS-ZAKZUK, NELSON J.; Diaz-Jimenez, D; Chaparro-Narváez, Pablo; Florez Tanus, Alvaro Javier; Castañeda-Orjuela, Carlos; Alvis-Guzmán, Nelson (Elsevier Ltd.United Kingdom, 2022)

To estimate and analyze cancer mortality trends in Colombia, 1979–2019. Ecological study of cancer mortality trends in Colombia. We obtained individual and anonymized records from death certificates gathered by the Colombian ...

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The burden of carbohydrates in health and disease
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Clemente-Suárez, Vicente Javier | 2022-09-15

Foods high in carbohydrates are an important part of a healthy diet, since they provide the body with glucose to support bodily functions and physical activity. However, the abusive consumption of refined, simple, and low-quality carbohydrates has a direct implication on the physical and mental pathophysiology. Then, carbohydrate consumption is postulated as a crucial factor in the development of the main Western diseases of the 21st century. We conducted this narrative critical review using MedLine (Pubmed), Cochrane (Wiley), Embase, and CinAhl databases with the MeSH-compliant keywords: carbohydrates and evolution, development, phylogenetic, GUT, microbiota, stress, metabolic health, consumption behaviors, metabolic disease, cardiovascular disease, mental disease, anxiety, depression, cancer, chronic kidney failure, allergies, and asthma in order to analyze the impact of carbohydrates on health. Evidence suggests that carbohydrates, especially fiber, are beneficial for the well-being and growth of gut microorganisms and consequently for the host in this symbiotic relationship, producing microbial alterations a negative effect on mental health and different organic systems. In addition, evidence suggests a negative impact of simple carbohydrates and refined carbohydrates on mood categories, including alertness and tiredness, reinforcing a vicious circle. Regarding physical health, sugar intake can affect the development and prognosis of metabolic disease, as an uncontrolled intake of refined carbohydrates puts individuals at risk of developing metabolic syndrome and subsequently developing metabolic disease.

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Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019
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Kocarnik, Jonathan | 2022

Importance The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. Objective To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. Evidence Review The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). Findings In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles. Conclusions and Relevance The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.

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Environmental and human health risks associated with exposure to hazardous elements present in urban dust from Barranquilla, Colombian Caribbean
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Osorio‐Martinez, Jorge | 2021-01-22

Urban dust is a mixture of deposited particles from different sources usually linked to potentially toxic elements (PTEs). Despite the industrialization of many South American countries, little is known about the impact of particulate matter in large cities, data necessary to promote environmental policies aiming to protect human health. The main objective of this work was to evaluate the particle size distribution, composition, as well as environmental and human health risks of settled dust particles from Barranquilla, a Colombian Caribbean industrialized area. Trace elements were analyzed by ICP‐MS from thirty‐five different sites, covering all city areas. Dust was mostly composed of 10–70 μm particles. The average concentrations of V, Cr, Mn, Co, Ni, Cu, Zn, As, Se, Mo, Ag, Cd, Sn, Sb, Pb, and Bi were above background. High spatial heterogeneity was observed for Cu, Zn, As, Se, Mo, Ag, Sn, Sb, and Bi. Concentration factors suggest urban dusts are extremely contaminated by Zn and Cu. The ecological risk associated with specific elements decreased in the order Cd > Cu > As > Hg > Pb > Ni > Co ≈ Zn ≈ Cr, and the contamination load index showed that 91% of the samples are polluted by PTEs. Although the carcinogenic risks of Cr, Ni, As, Co, and Cd were low, chronic exposure to several PTEs may be impacting the quality of life. Educational programs, as well as monitoring and greater control on traffic, industry, and construction activities, are needed in order to protect environmental and human health

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Evaluación del cumplimiento de la resolución 1441 de 2013 en el Instituto Oncohematologico Biobetania de la Ciudad de Barranquilla
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Olivares Flórez, Arelys | 2014-03-10

Treatments for such sensitive diseases such as cancer can not be subject to procedures that do not guarantee the quality of them, being the way that is necessary assessment processes in regard to medical processes. Therefore, the evaluation of resolution 1441 of 2013 at the Institute oncohematologic Biobetania of Barranquillacity. Through a descriptive methodology it was possible to evaluate each of the aspects covered in the standard 1441 on chemotherapy treatments at the institute oncohematologic Biobetania of Barranquillacity. Could detailing compliance in many dimensions, from the human research to professional interdependence at the level of complex health intervention level.

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The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019
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Bao Tran, Khanh | 2022-08

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk–outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01–4·94) deaths and 105 million (95·0–116) DALYs for both sexes combined, representing 44·4% (41·3–48·4) of all cancer deaths and 42·0% (39·1–45·6) of all DALYs. There were 2·88 million (2·60–3·18) risk-attributable cancer deaths in males (50·6% [47·8–54·1] of all male cancer deaths) and 1·58 million (1·36–1·84) risk-attributable cancer deaths in females (36·3% [32·5–41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6–28·4) and DALYs by 16·8% (8·8–25·0), with the greatest percentage increase in metabolic risks (34·7% [27·9–42·8] and 33·3% [25·8–42·0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden.

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Nutritional and exercise interventions in cancer-related cachexia: an extensive narrative review
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Clemente-Suárez, Vicente Javier | 2022-04-11

One of the common traits found in cancer patients is malnutrition and cachexia, which affects between 25% to 60% of the patients, depending on the type of cancer, diagnosis, and treatment. Given the lack of current effective pharmacological solutions for low muscle mass and sarcopenia, holistic interventions are essential to patient care, as well as exercise and nutrition. Thus, the present narrative review aimed to analyze the nutritional, pharmacological, ergonutritional, and physical exercise strategies in cancer-related cachexia. The integration of multidisciplinary interventions could help to improve the final intervention in patients, improving their prognosis, quality of life, and life expectancy. To reach these aims, an extensive narrative review was conducted. The databases used were MedLine (PubMed), Cochrane (Wiley), Embase, PsychINFO, and CinAhl. Cancer-related cachexia is a complex multifactorial phenomenon in which systemic inflammation plays a key role in the development and maintenance of the symptomatology. Pharmacological interventions seem to produce a positive effect on inflammatory state and cachexia. Nutritional interventions are focused on a high-energy diet with high-density foods and the supplementation with antioxidants, while physical activity is focused on strength-based training. The implementation of multidisciplinary non-pharmacological interventions in cancer-related cachexia could be an important tool to improve traditional treatments and improve patients’ quality of life.

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Trends in cancer mortality in Colombia, 1979-2019
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ALVIS-ZAKZUK, NELSON J. | 2022

To estimate and analyze cancer mortality trends in Colombia, 1979–2019. Ecological study of cancer mortality trends in Colombia. We obtained individual and anonymized records from death certificates gathered by the Colombian statistics bureau. Crude and age-standardized mortality rates (AMR) were calculated expressed in deaths per 100,000 inhabitants. For the adjustment of mortality rates by age, the direct method was used. The trend in mortality rates by sex and age was modeled using Joinpoint regression analysis. Annual percent change (APC) and the estimated. Between 1979-2019, 1,194,207 of cancer deaths occurred in Colombia (annual average: 29,127 deaths), 51.6% were in women (p <0.05). For men, AMR diminished from 110.4 in the 80s to 89.7 in 2019, and from 125.7 to 79.1 per 100.000 in women, respectively. In 65+, age-specific mortality rates were higher for men than for women. In men, between 1979-1981, AMR increased 16.1% (APC: 16.1% 95%CI 8.1-24.6) per year, and between 1981-1995 increased 0.6% (APC 0.6% 95%CI 0.2-0.9) per year. From 1998 to. The downward trend in cancer mortality rates in Colombian population is probably due to variations in prevalence and changes in risk factors such as fatality associated with access to healthcare services, as well as demographic and environmental changes.

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Listar por tema "Cancer"

The burden of carbohydrates in health and disease ﻿

Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019 ﻿

Environmental and human health risks associated with exposure to hazardous elements present in urban dust from Barranquilla, Colombian Caribbean ﻿

Evaluación del cumplimiento de la resolución 1441 de 2013 en el Instituto Oncohematologico Biobetania de la Ciudad de Barranquilla ﻿

The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019 ﻿

Nutritional and exercise interventions in cancer-related cachexia: an extensive narrative review ﻿

Trends in cancer mortality in Colombia, 1979-2019 ﻿

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The burden of carbohydrates in health and disease

Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019

Environmental and human health risks associated with exposure to hazardous elements present in urban dust from Barranquilla, Colombian Caribbean

Evaluación del cumplimiento de la resolución 1441 de 2013 en el Instituto Oncohematologico Biobetania de la Ciudad de Barranquilla

The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019

Nutritional and exercise interventions in cancer-related cachexia: an extensive narrative review

Trends in cancer mortality in Colombia, 1979-2019

The burden of carbohydrates in health and disease

Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019

Environmental and human health risks associated with exposure to hazardous elements present in urban dust from Barranquilla, Colombian Caribbean

Evaluación del cumplimiento de la resolución 1441 de 2013 en el Instituto Oncohematologico Biobetania de la Ciudad de Barranquilla

The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019

Nutritional and exercise interventions in cancer-related cachexia: an extensive narrative review

Trends in cancer mortality in Colombia, 1979-2019