Navegação por assunto "Inflammation"
Itens para a visualização no momento 1-6 of 6
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BRCA-1 depletion impairs pro-inflammatory polarization and activation of RAW 264.7 macrophages in a NF-κB-dependent mechanism
(Universidad de la Costa, 2019-12)BRCA-1 is a nuclear protein involved in DNA repair, transcriptional regulation, and cell cycle control. Its involvement in other cellular processes has been described. Here, we aimed to investigate the role of BRCA-1 in ... -
Characterization and modulation of microglial phenotypes in an animal model of severe sepsis
(Journal of Cellular and Molecular Medicine, 2019-10-26)We aim to characterize the kinetics of early and late microglial phenotypes after systemic inflammation in an animal model of severe sepsis and the effects of minocycline on these phenotypes. Rats were subjected to CLP, ... -
Eugenol mitigated acute lung but not spermatic toxicity of C60 fullerene emulsion in mice
(Corporación Universidad de la Costa, 2021)C60 fullerene (C60) is a nano-pollutant that can damage the respiratory system. Eugenol exhibits significant anti-inflammatory and antioxidant properties. We aimed to investigate the time course of C60 emulsion-induced ... -
High fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation and oxidative stress
(Corporación Universidad de la Costa, 2020-10-20)Obesity is a health problem that has been associated with neuroinflammation, decreased cognitive functions and development of neurodegenerative diseases. Parkinson’s disease (PD) is a chronic neurodegenerative condition ... -
Obese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese rats
(Ecotoxicology And Environmental Safety, 2018-08-26)Obesity is an important nutritional disorder worldwide. Its association with environmental pollution may trigger an increase in oxidative stress and inflammatory parameters. Coal is a resource used throughout the world as ... -
Obesity associated with coal ash inhalation triggers systemic inflammation and oxidative damage in the hippocampus of rats
(Universidad de la Costa, 2019)People with large amounts of adipose tissue are more vulnerable and more likely to develop diseases where oxidative stress and inflammation play a pivotal role, than persons with a healthy weight. Atmospheric contamination ...