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Environmental factors between normal and superagers in an argentine cohort

Calandri, Ismael Luis; Crivelli, Lucía; Martín, María Eugenia; Egido, Noelia; Magrath Guimet, Nahuel; Allegri, Ricardo Francisco (Corporación Universidad de la Costa, 2020-12-11)

Normal aging usually brings age-related cognitive decline. However, there is a group of aged individuals who have exceptional memory performance: the superagers. Objective: Our aim was to identify the environmental ...
Impaired theory of mind in unaffected first-degree relatives of patients with anorexia nervosa

Tapajóz, Fernanda; Soneira, Sebastián; Catoira, Natalia; Aulicino, Alfredo; Allegri, Ricardo F. (Corporación Universidad de la Costa, 2019)

Objective Previous studies have shown theory of mind (ToM) is affected in patients with anorexia nervosa (AN). There has also been growing interest in the study of endophenotypes in psychiatric disorders, since they allow ...
Neuropsychological profile of Alzheimer's disease based on amyloid biomarker findings results from a South American cohort.

Clarens, Maria Florencia; Crivelli, Lucia; Calandri, Ismael Luis; Chrem Méndez, Patricio; Martin, María Eugenia; Russo, María Julieta; Campos, Jorge; Surace, Ezequiel; Vázquez, Silvia; Sevlever, Gustavo; Allegri, Ricardo Francisco (Corporación Universidad de la Costa, 2020)

Objective: Increased life expectancy and exponential growth of adults suffering from Alzheimer's disease (AD) worldwide, has led to biomarkers incorporation for diagnosis in early stages. Use of neuropsychological testing ...

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Environmental factors between normal and superagers in an argentine cohort
...
Calandri, Ismael Luis | 2020-12-11

Normal aging usually brings age-related cognitive decline. However, there is a group of aged individuals who have exceptional memory performance: the superagers. Objective: Our aim was to identify the environmental factors that could influence exceptional memory performance in a cohort of Argentine individuals. Methods: Forty healthy volunteers >80 years of age were classified into two groups, superagers (SA, n=20) and normal agers (NA, n=20), according to the Northwestern SuperAging Program criteria. Participants were neuropsychologically tested and evaluated on environmental aspects: working status, education, bilingualism, cognitive reserve, physical activity, social networking, clinical comorbidities, and longevity of parents and siblings. Results: Both groups were highly educated (NA=16.3±3 years; SA 15.85±2.6; p=0.6), 11.8% of the sample was still working without differences between groups. There were no differences in cognitive reserve inventory (p=0.7), physical activity engagement (p=0.423), or social network index (p=0.73). As for longevity, 44% of the siblings lived longer than 80 years of age (p=0.432) and maternal longevity was linked to SA (NA=46.7%; SA=80%; p=0.045). Conclusions: This study is a pilot approximation to the superaging population in Argentina. Our results suggest that environmental factors related to successful aging do not differentiate superaging. SA may depend on variables yet to be identified, probably of a genetic/metabolic order.

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Impaired theory of mind in unaffected first-degree relatives of patients with anorexia nervosa
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Tapajóz, Fernanda | 2019

Objective Previous studies have shown theory of mind (ToM) is affected in patients with anorexia nervosa (AN). There has also been growing interest in the study of endophenotypes in psychiatric disorders, since they allow better understanding of genetic mechanisms underlying different conditions, making them potential targets for future treatment. The goal of this study was to investigate whether ToM inefficiencies observed in patients with AN, are shared by unaffected first‐degree relatives. Method Performance on two ToM tasks (Reading the Mind in the Eyes and Faux Pas Test) were compared in 17 unaffected first‐degree relatives of AN patients and in 17 healthy individuals matched for age and level of education. Depression, anxiety, obsessive compulsive, and eating disorder symptoms were also assessed and correlated with ToM and clinical/demographic variables. Results Significant differences between groups were observed in all ToM tasks, with relatives of AN patients showing poorer performance. ToM assessment did not correlate with any clinical or demographic variable. Conclusions The preliminary results of this study suggest unaffected first‐degree relatives of AN patients display similar patterns of difficulty in ToM as reported previously for AN patients, supporting the hypothesis that ToM inefficiencies are a familial trait in this condition.

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Neuropsychological profile of Alzheimer's disease based on amyloid biomarker findings results from a South American cohort.
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Clarens, Maria Florencia | 2020

Objective: Increased life expectancy and exponential growth of adults suffering from Alzheimer's disease (AD) worldwide, has led to biomarkers incorporation for diagnosis in early stages. Use of neuropsychological testing remains limited. This study aimed to identify which neuropsychological tests best indicated underlying AD pathophysiology.Methods: One hundred and forty-one patients with MCI (Mild Cognitive Impairment) were studied. A neuropsychological test battery based on the Uniform Data Set (UDS) from the Alzheimer's Disease Centers program of the National Institute on Aging (NIA) was performed and amyloid markers recorded; according to presence or absence of amyloid identified by positive PIB-PET findings, or low CSF Aβ42 levels, patients were separated into MCI amyloid-(n:58) and MCI amyloid + (n = 83) cases.Results: Statistical differences were found in all memory tests between groups. Delayed recall score at thirty minutes on the Rey Auditory Verbal Learning Test (AVLT) was the best predictor of amyloid pathology presence (AUC 0.68), followed by AVLT total learning (AUC 0.66) and AVLT Recognition (AUC 0.59) scores, providing useful cut off values in the clinical setting.Conclusions: Use of neuropsychological testing, specifically AVLT scores with cutoff values, contributed to the correct diagnosis of MCI due to AD in this SouthAmerican cohort

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Listar por tema "neuropsychology"

Environmental factors between normal and superagers in an argentine cohort ﻿

Impaired theory of mind in unaffected first-degree relatives of patients with anorexia nervosa ﻿

Neuropsychological profile of Alzheimer's disease based on amyloid biomarker findings results from a South American cohort. ﻿

Envíos recientes

Environmental factors between normal and superagers in an argentine cohort

Impaired theory of mind in unaffected first-degree relatives of patients with anorexia nervosa

Neuropsychological profile of Alzheimer's disease based on amyloid biomarker findings results from a South American cohort.

Environmental factors between normal and superagers in an argentine cohort

Impaired theory of mind in unaffected first-degree relatives of patients with anorexia nervosa

Neuropsychological profile of Alzheimer's disease based on amyloid biomarker findings results from a South American cohort.