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Universidad de la Costa, CUC. Calle 58 # 55 - 66. Barranquilla, Colombia. 336 22 00. repositorioredicuc@cuc.edu.co. Corporación Universidad de la Costa.

In vitro genotoxic effect of secondary minerals crystallized in rocks from coal mine drainage

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In Vitro Genotoxic Effect Of Secondary (230.6Kb)
Date
2018-03
Author
Perachi Nordin, Adriane
Da Silva, Juliana
Telles De Souza, Claudia
Niekraszewiczl Boufleur, Liana Appe
Ferraz Dias, Johnny
Da Boit Martinello, Katia
Silva Oliveira, Marcos Leandro
Grivicich, Ivana
Garcia Hilario, Ana Leticia
Silva Oliveira, Luis Felipe
Da Silva Rabaioli, Fernanda
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URI: http://hdl.handle.net/11323/1573
Citar con DOI: https://doi.org/10.1016/j.jhazmat.2017.12.026

Abstract

Coal processing generates a large volume of waste that can damage human health and the environment. Often these wastes produce acid drainage in which several minerals are crystallized (evaporites). This study aimed to identify secondary minerals, as well as the genotoxic potential of these materials. The samples were collected at two sites along the Rocinha River in Santa Catarina state (Brazil): (1) directly from the source of the acid drainage (evaporite 1), and (2) on the river bank (evaporite 2). The samples were characterized by X-ray diffraction and by particle-induced X-ray emission techniques. In vitro genotoxicity testing using Comet assay and Micronucleus test in V79 cells was used to evaluate evaporite samples. Our study also used System Biology tools to provide insight regarding the influence of this exposure on DNA damage in cells. The results showed that the samples induced DNA damage for both evaporites that can be explained by high concentrations of chromium, iron, nickel, copper and zinc in these materials. Thus, this study is very important due to the dearth of knowledge regarding the toxicity of evaporites in the environment. The genetic toxicity of this material can be induced by increased oxidative stress and DNA repair inhibition.
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Universidad de la Costa, CUC

  • Calle 58 # 55 - 66. Barranquilla, Colombia

  • 336 22 00

  • repositorioredicuc@cuc.edu.co

Corporación Universidad de la Costa CUC, Personería Jurídica con Resolución No. 352 del 23 de abril de 1971 y reconocida como Universidad mediante resolución 3235 del 28 de marzo de 2012 expedida por el MEN. Institución de Educación Superior sujeta a inspección y vigilancia por el Ministerio de Educación Nacional.

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