Show simple item record

dc.creatorRodríguez, Gonzalo
dc.creatorNargoli, Javier
dc.creatorLópez, Andrés
dc.creatorMoyna, Guillermo
dc.creatorÁlvarez, Guzmán
dc.creatorFernández, Marcelo
dc.creatorOsorio Martinez, Carlos Alberto
dc.creatorGonzález, Mercedes Florencia
dc.creatorCerecetto, Hugo Eduardo
dc.date.accessioned2018-11-27T14:27:14Z
dc.date.available2018-11-27T14:27:14Z
dc.date.issued2017-01-07
dc.identifier.issn20462069
dc.identifier.urihttp://hdl.handle.net/11323/1935
dc.description.abstractThe potential use of amide-containing thiazoles, especially (2E,2Z)-3-allyl-4-[((E)-4-cinnamylpiperazin-1-yl)carbonyl]-2-[2-((E)-3-(furan-2-yl)propenylidene)hydrazono]-2,3-dihydrothiazole (1), as drugs for the treatment of Chagas disease has been recently described. The therapeutic application of 1 requires further pre-clinical studies, including in vivo biodistribution. In this sense, a BODIPY-fluorophore based probe for this drug (1-BODIPY) was developed and investigated for its potential as an in vivo tracer. The fluorescent tracer was synthesized, physicochemically and in vitro biologically characterised, and its in vivo biodistribution evaluated. The in vitro studies demonstrated that the fluorescent probe could simulate the in vivo behaviour of compound 1. Furthermore, the in vivo proof of concept showed that the 1-BODIPY biodistribution involves organs that are associated with the parasitic disease. These findings allow us to establish future administration routes and regimens in the treatment of Chagas disease with 1.spa
dc.language.isoengeng
dc.publisherRSC Advanceseng
dc.rightsAtribución – No comercial – Compartir igualeng
dc.subjectBiodistributionseng
dc.subjectChagas diseaseeng
dc.subjectFluorescent probeseng
dc.subjectFluorescent tracerseng
dc.subjectIn-vitroeng
dc.subjectPre-clinicaleng
dc.subjectProof of concepteng
dc.subjectTherapeutic Applicationeng
dc.titleSynthesis and in vivo proof of concept of a BODIPY-based fluorescent probe as a tracer for biodistribution studies of a new anti-Chagas agenteng
dc.typeArticleeng


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record