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dc.contributor.authorRodríguez, Gonzalospa
dc.contributor.authorNargoli, Javierspa
dc.contributor.authorLópez, Andrésspa
dc.contributor.authorMoyna, Guillermospa
dc.contributor.authorÁlvarez, Guzmánspa
dc.contributor.authorFernández, Marcelospa
dc.contributor.authorOsorio Martinez, Carlos Albertospa
dc.contributor.authorGonzález, Mercedes Florenciaspa
dc.contributor.authorCerecetto, Hugo Eduardospa
dc.date.accessioned2018-11-27T14:27:14Z
dc.date.available2018-11-27T14:27:14Z
dc.date.issued2017-01-07
dc.identifier.issn20462069spa
dc.identifier.urihttp://hdl.handle.net/11323/1935spa
dc.description.abstractThe potential use of amide-containing thiazoles, especially (2E,2Z)-3-allyl-4-[((E)-4-cinnamylpiperazin-1-yl)carbonyl]-2-[2-((E)-3-(furan-2-yl)propenylidene)hydrazono]-2,3-dihydrothiazole (1), as drugs for the treatment of Chagas disease has been recently described. The therapeutic application of 1 requires further pre-clinical studies, including in vivo biodistribution. In this sense, a BODIPY-fluorophore based probe for this drug (1-BODIPY) was developed and investigated for its potential as an in vivo tracer. The fluorescent tracer was synthesized, physicochemically and in vitro biologically characterised, and its in vivo biodistribution evaluated. The in vitro studies demonstrated that the fluorescent probe could simulate the in vivo behaviour of compound 1. Furthermore, the in vivo proof of concept showed that the 1-BODIPY biodistribution involves organs that are associated with the parasitic disease. These findings allow us to establish future administration routes and regimens in the treatment of Chagas disease with 1.spa
dc.language.isoeng
dc.publisherRSC Advancesspa
dc.rightsAtribución – No comercial – Compartir igualspa
dc.subjectBiodistributionseng
dc.subjectChagas diseaseeng
dc.subjectFluorescent probeseng
dc.subjectFluorescent tracerseng
dc.subjectIn-vitroeng
dc.subjectPre-clinicaleng
dc.subjectProof of concepteng
dc.subjectTherapeutic Applicationeng
dc.titleSynthesis and in vivo proof of concept of a BODIPY-based fluorescent probe as a tracer for biodistribution studies of a new anti-Chagas agenteng
dc.typeArtículo de revistaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.identifier.instnameCorporación Universidad de la Costaspa
dc.identifier.reponameREDICUC - Repositorio CUCspa
dc.identifier.repourlhttps://repositorio.cuc.edu.co/spa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa


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