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dc.creatorGasparotto, Juciano
dc.creatorRodrigues Chaves, Paloma
dc.creatorBoit Martinello, Katiada
dc.creatorSilva Oliveira, Luis Felipe
dc.creatorPens Gelain, Daniel
dc.creatorFonseca Moreira, José Claudio
dc.date.accessioned2019-08-29T15:32:33Z
dc.date.available2019-08-29T15:32:33Z
dc.date.issued2019
dc.identifier.urihttp://hdl.handle.net/11323/5218
dc.description.abstractPeople with large amounts of adipose tissue are more vulnerable and more likely to develop diseases where oxidative stress and inflammation play a pivotal role, than persons with a healthy weight. Atmospheric contamination is a reality to which a large part of the worldwide population is exposed. Half of today's global electrical energy is derived from coal. Each organism, in its complexity, responds in different ways to dietary compounds and air pollution. The objective of this study was to investigate the effects of obesity and coal ash inhalation within the parameters of oxidative damage and inflammation in different regions of the brain of rats. A diet containing high-fat concentration was administered chronically to rats, along with exposure to coal ash, simulating the contamination that occurs daily throughout human life. High-resolution transmission electron microscopy was performed to identify the particles present in coal ash samples. Our results demonstrated that obese rats exposed to coal ash inhalation were more affected by oxidative damage with subsequent systemic inflammation in the hippocampus. Since there is an inflammatory predisposition caused by obesity, the inhalation of nanoparticles increases the levels of free radicals, resulting in systemic inflammation and oxidative damage, which can lead to chronic neurodegeneration.spa
dc.language.isoengspa
dc.publisherUniversidad de la Costaspa
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectObesogenic dietspa
dc.subjectAir pollutionspa
dc.subjectHippocampusspa
dc.subjectOxidative damagespa
dc.subjectInflammationspa
dc.titleObesity associated with coal ash inhalation triggers systemic inflammation and oxidative damage in the hippocampus of ratsspa
dc.typePreprintspa
dc.type.hasVersioninfo:eu-repo/semantics/draftspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa


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