Show simple item record

dc.creatorda Rosa-Silva, Helen Tais
dc.creatorCastro Panzenhagen, Alana
dc.creatorSchmidtt, Victória
dc.creatorAlves Teixeira, Alexsander
dc.creatorEspitia-Pérez, Pedro
dc.creatorde Oliveira Franco, Álvaro
dc.creatorMingori, Moara
dc.creatorTorres-Ávila, José F.
dc.creatorSchnorr, Carlos Eduardo
dc.creatorSilva Hermann, Paolla Rissi
dc.creatorPompéu Moraes, Diogo
dc.creatorFarina Almeida, Roberto
dc.creatorMoreira, José Cláudio Fonseca
dc.date.accessioned2020-05-04T22:12:13Z
dc.date.available2020-05-04T22:12:13Z
dc.date.issued2020
dc.identifier.urihttps://hdl.handle.net/11323/6248
dc.description.abstractMethylmercury (MeHg) is an organic bioaccumulated mercury derivative that strongly affects the environment and represents a public health problem primarily to riparian communities in South America. Our objective was to investigate the hepatic and neurological effects of MeHg exposure during the phases foetal and breast-feeding and adult in Wistar rats. Wistar rats (n = 10) were divided into 3 groups. Control group received mineral oil; The simple exposure (SE) group was exposed only in adulthood (0.5 mg/kg/day); and double exposure (DE) was pre-exposed to MeHg 0.5 mg/kg/day during pregnancy and breastfeeding (±40 days) and re-exposed to MeHg for 45 days from day 100. After, we evaluated possible abnormalities. Behavioral and biochemical parameters in liver and occipital cortex (CO), markers of liver injury, redox and AKT/GSK3β/mTOR signaling pathway. Our results showed that both groups treated with MeHg presented significant alterations, such as decreased locomotion and exploration and impaired visuospatial perception. The rats exposed to MeHg showed severe liver damage and increased hepatic glycogen concentration. The MeHg groups showed significant impairment in redox balance and oxidative damage to liver macromolecules and CO. MeHg upregulated the AKT/GSK3β/mTOR pathway and the phosphorylated form of the Tau protein. In addition, we found a reduction in NeuN and GFAP immunocontent. These results represent the first approach to the hepatotoxic and neural effects of foetal and adult MeHg exposure.spa
dc.language.isoengspa
dc.publisherUniversidad de la Costaspa
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectMethylmercuryspa
dc.subjectDouble exposurespa
dc.subjectOxidative stressspa
dc.subjectHepatotoxicityspa
dc.subjectNeurotoxicityspa
dc.subjectAkt/GSK3β/mTOR pathwayspa
dc.titleHepatic and neurobiological effects of foetal and breastfeeding and adulthood exposure to methylmercury in Wistar ratsspa
dc.typePreprintspa
dc.type.hasVersioninfo:eu-repo/semantics/draftspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.identifier.doihttps://doi.org/10.1016/j.chemosphere.2019.125400


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

CC0 1.0 Universal
Except where otherwise noted, this item's license is described as CC0 1.0 Universal