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dc.creatorda Silva Bittencourt, Leonardo
dc.creatorSchnorr, Carlos Eduardo
dc.creatorCopetti Santos, Daniela
dc.creatorRostirolla, Diana Carolina
dc.creatorMoresco, Karla
dc.creatorOzório, Pedro
dc.creatorRodrigues Mingori, Moara
dc.creatorHeinfarth, Luana
dc.creatorGelain, Daniel
dc.creatorMoreira, José Cláudio Fonseca
dc.description.abstractPrevious studies have reported that acrolein, may exert harmful effects on the brain. However, information regarding the neuroprotective properties of guarana against acrolein is not available. Due to the lack of research, we initiated the current study to investigate the effects of guarana extracts on acrolein-induced toxicity in the liver and the central nervous system of Wistar Rats. Twelve groups of 60 days old Wistar rats treated with guarana extracts (150, 250, and 350 mg/kg/day) for 8 weeks, were challenged with acrolein (2.5 mg/kg/day). Several parameters associated with oxidative damage to the brain and hepatic function, as well as behavior were evaluated. All tested concentrations of guarana extracts exerted protective effects against acrolein induced damage. No hepatic and oxidative damages or behavioral changes were observed in guarana control groups. To the best of our knowledge, this is the first study of its kind and therefore a milestone in this
dc.description.abstractEstudios anteriores han informado que la acroleína puede ejercer efectos nocivos en el cerebro. Sin embargo, no se dispone de información sobre las propiedades neuroprotectoras del guaraná contra la acroleína. Debido a la falta de investigación, iniciamos el estudio actual para investigar los efectos de los extractos de guaraná sobre la toxicidad inducida por acroleína en el hígado y el sistema nervioso central de las ratas Wistar. Doce grupos de ratas Wistar de 60 días de edad tratadas con extractos de guaraná (150, 250 y 350 mg / kg / día) durante 8 semanas, fueron desafiados con acroleína (2.5 mg / kg / día). Se evaluaron varios parámetros asociados con el daño oxidativo del cerebro y la función hepática, así como el comportamiento. Todas las concentraciones probadas de extractos de guaraná ejercieron efectos protectores contra el daño inducido por acroleína. No se observaron daños hepáticos y oxidativos o cambios de comportamiento en los grupos de control de guaraná. Hasta donde sabemos, este es el primer estudio de este tipo y, por lo tanto, un hito en este
dc.publisherCorporación Universidad de la Costaspa
dc.rightsCC0 1.0 Universal*
dc.sourceJournal of Functional Foodsspa
dc.subjectOxidative stressspa
dc.subjectCognitive impairmentspa
dc.subjectNeurogenerative diseasesspa
dc.subjectEstrés oxidativospa
dc.subjectDeterioro cognitivospa
dc.subjectEnfermedades neurogenerativasspa
dc.titleChronic acrolein exposure in wistar rats: the effects of guarana extractsspa
dc.title.alternativeExposición crónica a acroleína en ratas wistar: los efectos de los extractos de guaranáspa
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