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dc.contributor.authorda Silva Bittencourt, Leonardospa
dc.contributor.authorSchnorr, Carlos Eduardospa
dc.contributor.authorCopetti Santos, Danielaspa
dc.contributor.authorRostirolla, Diana Carolinaspa
dc.contributor.authorMoresco, Karlaspa
dc.contributor.authorOzório, Pedrospa
dc.contributor.authorRodrigues Mingori, Moaraspa
dc.contributor.authorHeinfarth, Luanaspa
dc.contributor.authorGelain, Danielspa
dc.contributor.authorMoreira, José Cláudio Fonsecaspa
dc.date.accessioned2020-11-04T14:47:23Z
dc.date.available2020-11-04T14:47:23Z
dc.date.issued2019-12-04
dc.identifier.issn17564646spa
dc.identifier.urihttps://hdl.handle.net/11323/7200spa
dc.description.abstractPrevious studies have reported that acrolein, may exert harmful effects on the brain. However, information regarding the neuroprotective properties of guarana against acrolein is not available. Due to the lack of research, we initiated the current study to investigate the effects of guarana extracts on acrolein-induced toxicity in the liver and the central nervous system of Wistar Rats. Twelve groups of 60 days old Wistar rats treated with guarana extracts (150, 250, and 350 mg/kg/day) for 8 weeks, were challenged with acrolein (2.5 mg/kg/day). Several parameters associated with oxidative damage to the brain and hepatic function, as well as behavior were evaluated. All tested concentrations of guarana extracts exerted protective effects against acrolein induced damage. No hepatic and oxidative damages or behavioral changes were observed in guarana control groups. To the best of our knowledge, this is the first study of its kind and therefore a milestone in this field.spa
dc.description.abstractEstudios anteriores han informado que la acroleína puede ejercer efectos nocivos en el cerebro. Sin embargo, no se dispone de información sobre las propiedades neuroprotectoras del guaraná contra la acroleína. Debido a la falta de investigación, iniciamos el estudio actual para investigar los efectos de los extractos de guaraná sobre la toxicidad inducida por acroleína en el hígado y el sistema nervioso central de las ratas Wistar. Doce grupos de ratas Wistar de 60 días de edad tratadas con extractos de guaraná (150, 250 y 350 mg / kg / día) durante 8 semanas, fueron desafiados con acroleína (2.5 mg / kg / día). Se evaluaron varios parámetros asociados con el daño oxidativo del cerebro y la función hepática, así como el comportamiento. Todas las concentraciones probadas de extractos de guaraná ejercieron efectos protectores contra el daño inducido por acroleína. No se observaron daños hepáticos y oxidativos o cambios de comportamiento en los grupos de control de guaraná. Hasta donde sabemos, este es el primer estudio de este tipo y, por lo tanto, un hito en este campo.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isoeng
dc.publisherCorporación Universidad de la Costaspa
dc.rightsCC0 1.0 Universalspa
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/spa
dc.sourceJournal of Functional Foodsspa
dc.subject2-Propenalspa
dc.subjectOxidative stressspa
dc.subjectGuaranaspa
dc.subjectPolyphenolsspa
dc.subjectCognitive impairmentspa
dc.subjectNeurogenerative diseasesspa
dc.subjectEstrés oxidativospa
dc.subjectGuaranáspa
dc.subjectPolifenolesspa
dc.subjectDeterioro cognitivospa
dc.subjectEnfermedades neurogenerativasspa
dc.titleChronic acrolein exposure in wistar rats: the effects of guarana extractsspa
dc.typeArtículo de revistaspa
dc.source.urlhttps://www.sciencedirect.com/science/article/pii/S1756464619306577?via%3Dihubspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.identifier.doihttps://doi.org/10.1016/j.jff.2019.103733spa
dc.identifier.instnameCorporación Universidad de la Costaspa
dc.identifier.reponameREDICUC - Repositorio CUCspa
dc.identifier.repourlhttps://repositorio.cuc.edu.co/spa
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dc.title.translatedExposición crónica a acroleína en ratas wistar: los efectos de los extractos de guaranáspa
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