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dc.creatorChrem Mendez, Patricio
dc.creatorSurace, Ezequiel
dc.creatorBérgamo, Yanina
dc.creatorCalandri, Ismael
dc.creatorVázquez, Silvia
dc.creatorSevlever, Gustavo
dc.creatorAllegri, Ricardo Francisco
dc.date.accessioned2020-11-19T19:44:22Z
dc.date.available2020-11-19T19:44:22Z
dc.date.issued2019
dc.identifier.urihttps://hdl.handle.net/11323/7372
dc.description.abstractBiomarcadores de enfermedad de Alzheimer. Dónde estamos y hacia dónde vamos. La enfermedad de Alzheimer (EA) es uno de los mayores flagelos aún no resueltos que acompañan al aumento de la expectativa de vida. El gran cambio de paradigma en los últimos años fue consecuencia de descubrir que el depósito amiloideo se presenta hasta 20 años antes, y la degeneración neurofibrilar hasta 10 años antes, de que aparezca la sintomatología clínica típica de pérdida de memoria. La aparición de los biomarcadores permitió reestructurar el concepto de la EA, intentándose llegar a una definición molecular de la misma casi prescindiendo de la emblemática clínica. Existen distintos tipos de biomarcadores de EA disponibles en nuestro país. Cada uno nos habla de un proceso y un momento distinto de la enfermedad. Aunque su uso clínico aún se encuentra restringido por cuestiones de costos, existen escenarios particulares en donde sí se justifica, casi siempre en relación a presentaciones clínicas atípicas o de comienzo muy temprano. Sin embargo, hoy en día ya nadie discute que son imprescindibles en investigaciones clínicas sobre EA. La incorporación de biomarcadores en la práctica médica ha generado cambios significativos en la intervención terapéutica de los pacientes, incluso en un contexto en el que todavía no hay medicamentos modificadores de la enfermedad.spa
dc.description.abstractAlzheimer disease (AD) is one of the major unresolved health burdens accompanying the increase in life expectancy. The great paradigm shift for this disease has resulted from finding amyloid deposition and neurobrillary degeneration 20 years and 10 years, respectively, prior to onset of the typical clinical memory loss symptoms. The advent of AD biomarkers has enabled a molecular definition of AD, making the clinical definition almost dispensable. Various types of AD biomarkers are available in our country. Each biomarker reflects a particular process and stage of the disease. Although costs restrict their use, the biomarker analysis may be justified in certain clinical scenarios, such as an early onset or an atypical presentation of the disease. Today, the usefulness of biomarkers in AD clinical research is beyond question. Furthermore, the introduction of biomarkers into medical practice has led to significant changes in therapeutic interventions, even in the absence of disease-modifying drugs.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.publisherCorporación Universidad de la Costaspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceMEDICINA (Buenos Aires)spa
dc.subjectbiomarcadores de la enfermedad de Alzheimerspa
dc.subjectetapas preclínicasspa
dc.subjectneuroimágenesspa
dc.subjectdiagnóstico molecularspa
dc.titleBiomarkers for Alzheimer’s disease. Where we stand and where we are headedspa
dc.title.alternativeBiomarcadores de enfermedad de Alzheimer. Dónde estamos y hacia dónde vamosspa
dc.typearticlespa
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dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.source.urlhttp://www.medicinabuenosaires.com/PMID/31864224.pdfspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa


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