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dc.creatorFernández, Rodrigo S
dc.creatorAllegri, Ricardo
dc.date.accessioned2020-11-24T16:24:48Z
dc.date.available2020-11-24T16:24:48Z
dc.date.issued2019
dc.identifier.urihttps://hdl.handle.net/11323/7454
dc.description.abstractIntroducción En condiciones normales, nuestro cerebro es capaz de actualizar sus representaciones almacenadas en fuerza o contenido por el proceso de reconsolidación. De esta forma, una memoria consolidada es reactivada y entra en un periodo transitorio de inestabilidad seguido por una fase de reestabilización para persistir. El inicio del proceso de reconsolidación depende de la detección de una incongruencia entre la predicción realizada y lo ocurrido (error de predicción), en el que la predicción inicial se ajusta acorde al error generado. Desarrollo La neurociencia, la psicología y otras ciencias básicas han aportado perspectivas novedosas en la investigación y abordaje de diversos trastornos psiquiátricos. En este sentido, establecieron una relación íntima entre la memoria y las enfermedades mentales. El paradigma de la reconsolidación de la memoria ha sido propuesto no solo como el mecanismo responsable del mantenimiento de algunas psicopatologías sino también como una oportunidad de establecer nuevos tratamientos. En la presente revisión se desarrollará el concepto de reconsolidación, ampliamente estudiado en animales y humanos en los últimos 20 años, y se destacarán sus potenciales aplicaciones traslacionales a la clínica neuropsiquiátrica. Conclusiones Existen evidencias de que el proceso de reconsolidación tendría utilidad terapéutica en la clínica neuropsiquiátrica. Sin embargo, aún se requieren estudios mayores y más complejos.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.publisherCorporación Universidad de la Costaspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceNeurología Argentinaspa
dc.subjectMemoriaspa
dc.subjectReconsolidaciónspa
dc.subjectConsolidaciónspa
dc.subjectError de predicciónspa
dc.subjectTraslacionalspa
dc.subjectNeuropsiquiatríaspa
dc.titleAcerca de la inestabilidad de las memorias y su transformación por el proceso de reconsolidación: aportes para su consideración clínicaspa
dc.title.alternativeOn the instability of memories and its transformation by the reconsolidation process: Contributions for its clinical considerationspa
dc.typearticlespa
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dc.identifier.doihttps://doi.org/10.1016/j.neuarg.2019.06.002


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