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dc.contributor.authorGomes Pinheiro, Felipespa
dc.contributor.authorMoreira-Gomes, Maria Dianaspa
dc.contributor.authorNascimento Machado, Marianaspa
dc.contributor.authordos Santos Almeida, Tailanespa
dc.contributor.authorda Penha Apolinario Barboza, Priscilaspa
dc.contributor.authorSilva Oliveira, Luis Felipespa
dc.contributor.authorSales Avila Cavalcante, Franciscospa
dc.contributor.authorHenrique Leal-Cardoso, Josespa
dc.contributor.authorSoares Fortunato, Rodrigospa
dc.contributor.authorAraujo Zin, Walterspa
dc.date.accessioned2020-12-10T19:00:37Z
dc.date.available2020-12-10T19:00:37Z
dc.date.issued2021
dc.identifier.issn0269-7491spa
dc.identifier.issn1873-6424spa
dc.identifier.urihttps://hdl.handle.net/11323/7566spa
dc.description.abstractC60 fullerene (C60) is a nano-pollutant that can damage the respiratory system. Eugenol exhibits significant anti-inflammatory and antioxidant properties. We aimed to investigate the time course of C60 emulsion-induced pulmonary and spermatic harms, as well as the effect of eugenol on C60 emulsion toxicity. The first group of mice (protocol 1) received intratracheally C60 emulsion (1.0 mg/kg BW) or vehicle and were tested at 12, 24, 72 and 96 h (F groups) thereafter. The second group of mice (protocol 2) received intratracheally C60 emulsion or vehicle, 1 h later were gavaged with eugenol (150 mg/kg) or vehicle, and experiments were done 24 h after instillation. Lung mechanics, morphology, redox markers, cytokines and epididymal spermatozoa were analyzed. Protocol 1: Tissue damping (G) and elastance (H) were significantly higher in F24 than in others groups, except for H in F72. Morphological and inflammatory parameters were worst at 24 h and subsequently declined until 96 h, whereas redox and spermatic parameters worsened over the whole period. Eugenol eliminated the increase in G, H, cellularity, and cytokines, attenuated oxidative stress induced by C60 exposure, but had no effect on sperm. Hence, exposure to C60 emulsion deteriorated lung morphofunctional, redox and inflammatory characteristics and increased the risk of infertility. Furthermore, eugenol avoided those changes, but did not prevent sperm damage.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isoeng
dc.publisherCorporación Universidad de la Costaspa
dc.rightsCC0 1.0 Universalspa
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/spa
dc.sourceEnvironmental Pollutionspa
dc.subjectLung mechanicsspa
dc.subjectInflammationspa
dc.subjectOxidative stressspa
dc.subjectSperm vitalityspa
dc.subjectC60 toxicityspa
dc.titleEugenol mitigated acute lung but not spermatic toxicity of C60 fullerene emulsion in micespa
dc.typePre-Publicaciónspa
dc.source.urlhttps://www.sciencedirect.com/science/article/abs/pii/S0269749120368779spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.identifier.doihttps://doi.org/10.1016/j.envpol.2020.116188spa
dc.identifier.instnameCorporación Universidad de la Costaspa
dc.identifier.reponameREDICUC - Repositorio CUCspa
dc.identifier.repourlhttps://repositorio.cuc.edu.co/spa
dc.type.coarhttp://purl.org/coar/resource_type/c_816bspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/preprintspa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTOTRspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa


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