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dc.creatorNguyen, Kim
dc.creatorKubota, Miles
dc.creatorDel Arco, Jon
dc.creatorFeng, Chao
dc.creatorSingha, Monika
dc.creatorBeasley, Samantha
dc.creatorSakr, Jasmine
dc.creatorP. Gandhi, Sunil
dc.creatorBlurton-Jones, Mathew
dc.creatorFernández Lucas, Jesus
dc.creatorC. Spitale, Robert
dc.description.abstractProfiling RNA expression in a cell-specific manner continues to be a grand challenge in biochemical research. Bioorthogonal nucleosides can be utilized to track RNA expression; however, these methods currently have limitations due to background and incorporation of analogs into undesired cells. Herein, we design and demonstrate that uracil phosphoribosyltransferase can be engineered to match 5-vinyluracil for cell-specific metabolic labeling of RNA with exceptional specificity and
dc.publisherCorporación Universidad de la Costaspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.sourceACS Chemical Biologyspa
dc.subjectPeptides and proteinsspa
dc.subjectImaging probesspa
dc.titleA bump-hole strategy for increased stringency of cell-specific metabolic labeling of rnaspa
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