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dc.creatorDel Arco, Jon
dc.creatorAcosta, Javier
dc.creatorFernández-Lucas, Jesús
dc.date.accessioned2021-02-26T18:23:15Z
dc.date.available2021-02-26T18:23:15Z
dc.date.issued2021-01-27
dc.identifier.issn1873-1899
dc.identifier.issn0734-9750
dc.identifier.urihttps://hdl.handle.net/11323/7934
dc.description.abstractNowadays, pharmaceutical industry demands competitive and eco-friendly processes for active pharmaceutical ingredients (APIs) manufacturing. In this context, enzyme and whole-cell mediated processes offer an efficient, sustainable and cost-effective alternative to the traditional multi-step and environmentally-harmful chemical processes. Particularly, 2′-deoxyribosyltransferases (NDTs) have emerged as a novel synthetic alternative, not only to chemical but also to other enzyme-mediated synthetic processes. This review describes recent findings in the development and scaling up of NDTs as industrial biocatalysts, including the most relevant and recent examples of single enzymatic steps, multienzyme cascades, chemo-enzymatic approaches, and engineered biocatalysts. Finally, to reflect the inventive and innovative steps of NDT-mediated bioprocesses, a detailed analysis of recently granted patents, with specific focus on industrial synthesis of nucleoside-based APIs, is hereunder presented.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherCorporación Universidad de la Costaspa
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.sourceBiotechnology Advancesspa
dc.subjectBiocatalysisspa
dc.subjectTransglycosylationspa
dc.subject2′-deoxyribosyltransferasesspa
dc.subjectNucleoside analoguesspa
dc.titleNew trends in the biocatalytic production of nucleosidic active pharmaceutical ingredients using 2′-deoxyribosyltransferasesspa
dc.typePreprintspa
dc.source.urlhttps://www.sciencedirect.com/science/article/abs/pii/S0734975021000070spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.identifier.doihttps://doi.org/10.1016/j.biotechadv.2021.107701
dc.date.embargoEnd2022-01
dc.type.hasversioninfo:eu-repo/semantics/draftspa


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CC0 1.0 Universal
Except where otherwise noted, this item's license is described as CC0 1.0 Universal