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dc.creatorBittencourt, Aline
dc.creatorOzorio Brum, Pedro
dc.creatorTiefensee Ribeiro, Camila
dc.creatorGasparotto, Juciano
dc.creatorBortolin, Rafael Calixto
dc.creatorRodrigues de Vargas, Amanda
dc.creatorHeimfarth, Luana
dc.creatorFarina de Almeida, Roberto
dc.creatorMoreira, José Cláudio Fonseca
dc.creatorde Oliveira, Jade
dc.creatorPens Gelain, Daniel
dc.date.accessioned2021-03-10T13:49:36Z
dc.date.available2021-03-10T13:49:36Z
dc.date.issued2020-10-20
dc.identifier.issn14768305
dc.identifier.issn1028415X
dc.identifier.urihttps://hdl.handle.net/11323/7975
dc.description.abstractObesity is a health problem that has been associated with neuroinflammation, decreased cognitive functions and development of neurodegenerative diseases. Parkinson’s disease (PD) is a chronic neurodegenerative condition characterized by motor and non-motor abnormalities, increased brain inflammation, α-synuclein protein aggregation and dopaminergic neuron loss that is associated with decreased levels of tyrosine hydroxylase (TH) in the brain. Diet-induced obesity is a global epidemic and its role as a risk factor for PD is not clear. Herein, we showed that 25 weeks on a high-fat diet (HFD) promotes significant alterations in the nigrostriatal axis of Wistar rats. Obesity induced by HFD exposure caused a reduction in TH levels and increased TH phosphorylation at serine 40 in the ventral tegmental area. These effects were associated with insulin resistance, increased tumor necrosis factor-α levels, oxidative stress, astrogliosis and microglia activation. No difference was detected in the levels of α-synuclein. Obesity also induced impairment of locomotor activity, total mobility and anxiety-related behaviors that were identified in the open-field and light/dark tasks. There were no changes in motor coordination or memory. Together, these data suggest that the reduction of TH levels in the nigrostriatal axis occurs through an α-synuclein-independent pathway and can be attributed to brain inflammation, oxidative/nitrosative stress and metabolic disorders induced by obesityspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherCorporación Universidad de la Costaspa
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.sourceNutritional Neurosciencespa
dc.subjectObesityspa
dc.subjectParkinson’s diseasespa
dc.subjectTyrosine hydroxylasespa
dc.subjectInflammationspa
dc.subjectLocomotionspa
dc.subjectAnxietyspa
dc.subjectNeuroinflammationspa
dc.subjectHigh-fat dietspa
dc.titleHigh fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation and oxidative stressspa
dc.typePreprintspa
dcterms.referencesObesity in Aging Exacerbates Blood-Brain Barrier Disruption, Neuroinflammation, and Oxidative Stress in the Mouse Hippocampus: Effects on Expression of Genes Involved in Beta-Amyloid Generation and Alzheimer's Diseasespa
dc.source.urlhttps://www.tandfonline.com/doi/ref/10.1080/1028415X.2020.1831261?scroll=topspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.identifier.doihttps://doi.org/10.1080/1028415X.2020.1831261
dc.type.hasversioninfo:eu-repo/semantics/draftspa


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CC0 1.0 Universal
Except where otherwise noted, this item's license is described as CC0 1.0 Universal