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Riesgo de cáncer en agricultores expuestos a glifosato: una revisión sistemática y metaanálisis

dc.contributor.advisorSchnorr, Carlos Eduardospa
dc.contributor.advisorSilva Oliveira, Luis Felipespa
dc.contributor.authorLlanos Polo, Anyerisspa
dc.date.accessioned2021-04-21T20:06:59Z
dc.date.available2021-04-21T20:06:59Z
dc.date.issued2020
dc.identifier.citationLlanos, A. (2020) Riesgo de cáncer en agricultores expuestos a glifosato: una revisión sistemática y metaanálisis. Trabajo de Maestría. Recuperado de https://hdl.handle.net/11323/8172spa
dc.identifier.urihttps://hdl.handle.net/11323/8172spa
dc.description.abstractThe use of herbicides such as glyphosate has increased and at the same time general concern about the increased associated risks. Further, the Environmental Protection Agency-USEPA and the International Agency for Research on Cancer-IARC have discussed the possible association between glyphosate exposure and cancer in farmers reporting different results. Thus, the objective of this systematic review and meta-analysis was to evaluate the risk of cancer in farmers occupationally exposed to glyphosate. Cohort studies, case controls and systematic reviews were included, whose population was farmers exposed to glyphosate, and with a medical diagnosis of cancer. In total, 313 potential studies were identified, of which only 6 studies met the inclusion and exclusion criteria. The meta-analysis revealed a higher risk of non-Hodgkin lymphoma (OR 0.39; 95% CI = 0.35-0.41; Z = 31.37 and p<0.00001), and multiple myeloma (OR 0.04; 95% CI = 0.03-0.05; Z = 30.27 p <0.00001) in exposed farmers compared to farmers not exposed. These results are the basis for future studies on the potential carcinogenic effect in farmers who are exposed to glyphosate on a daily basis. Further, our results seek to contribute to establish safety and health standards for the protection of agricultural workers.eng
dc.description.abstractEl uso de herbicidas como el glifosato ha aumentado y paralelamente ha incrementado también la preocupación general acerca de los riesgos asociados. Incluso la Environmetal Protetion Agency- USEPA y la International Agency for Research on Cancer- IARC han debatido de la posible asociación entre la exposición al glifosato y el cáncer en agricultores obteniendo diferentes resultados. Así, el objetivo de esta revisión sistemática y metaanálisis fue evaluar el riesgo de cáncer en agricultores ocupacionalmente expuestos al glifosato. En la revisión fueron incluidos estudios de cohorte, casos control y revisiones sistemáticas, cuya población fueron agricultores expuesto al glifosato, y con diagnóstico médico de cáncer. En total se identificaron 313 estudios potenciales, de los cuales solo 6 estudios cumplieron con los criterios de inclusión y exclusión. El metaanálisis reveló un mayor riesgo de linfoma de no Hodgkin (OR 0,39; IC95%=0,35-0,41; Z= 31.37 y p< 0.00001), linfoma de Hodgkin (OR 0,36; IC95%= 0,15- 0,30; Z= 9.86 y p< 0.00001), y mieloma múltiple (OR 0,04; IC95%= 0,03- 0,05; Z= 30.27 p< 0.00001) en los agricultores expuestos en comparación con los agricultores no expuestos. Estos resultados son la base para estudios futuros sobre el potencial efecto cancerígeno en los agricultores que se exponen a diario al glifosato. Además, buscan contribuir para establecer normas de seguridad y salud en protección de los trabajadores agrícolas.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isospa
dc.publisherCorporación Universidad de la Costaspa
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 Internationalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.subjectHerbicideeng
dc.subjectFarmerseng
dc.subjectNeoplasmeng
dc.subjectHealtheng
dc.subjectRiskeng
dc.subjectExposureeng
dc.subjectHerbicidaspa
dc.subjectAgricultorspa
dc.subjectNeoplasiaspa
dc.subjectSaludspa
dc.subjectRiesgospa
dc.subjectExposiciónspa
dc.titleRiesgo de cáncer en agricultores expuestos a glifosato: una revisión sistemática y metaanálisisspa
dc.typeTrabajo de grado - Maestríaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.identifier.instnameCorporación Universidad de la Costaspa
dc.identifier.reponameREDICUC - Repositorio CUCspa
dc.identifier.repourlhttps://repositorio.cuc.edu.co/spa
dc.publisher.programMaestría de Investigación en Desarrollo Sostenible MIDESspa
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