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Estimating the impact of a gender-neutral quadrivalent human papillomavirus vaccination program in all hpv 6/11/16/18 -related diseases in Colombia
dc.contributor.author | De Los Angeles Carrasquilla, Maria | spa |
dc.contributor.author | ALVIS-ZAKZUK, NELSON J. | spa |
dc.contributor.author | Zakzuk Sierra, J | spa |
dc.contributor.author | Benavides De La Rosa, Fernanda | spa |
dc.contributor.author | Castello Beltran, Carlos | spa |
dc.contributor.author | Rojas, M | spa |
dc.contributor.author | Prieto, Esteban | spa |
dc.contributor.author | Yen, G | spa |
dc.contributor.author | Parellada, C | spa |
dc.contributor.author | Pavelyev, A | spa |
dc.date.accessioned | 2021-06-02T16:47:07Z | |
dc.date.available | 2021-06-02T16:47:07Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1098-3015 | spa |
dc.identifier.uri | https://hdl.handle.net/11323/8336 | spa |
dc.description.abstract | We assessed the public health and economic impact of adding males to the existing female-only quadrivalent HPV vaccine (4vHPV) program in Colombia, analyzing different gender-neutral vaccination (GNV) vaccine coverage rates (VCRs). A published HPV-type dynamic transmission model was used to compare female-only vaccination (FOV) versus GNV with two-dose 4vHPV in the 9-10-year-old cohort over a 100-year timeframe in Colombia. The model compared 35% VCR for FOV with GNV at VCRs of 35% (scenario A), 50% (scenario B) and different VCRs between females/males (50%/35%, scenario C). The predicted health outcomes included HPV 6/11/16/18-related disease and deaths averted [cervical intraepithelial neoplasia, cervical, vaginal, vulvar, penile, anal and head and neck cancers, genital warts (GW), and recurrent respiratory papillomatosis], direct healthcare cost prevented by vaccination, and incremental cost-effectiveness ratios (ICERs). All GNV scenarios are estimated to provide faster and greater reductions in HPV 6/11/16/18-related diseases relative to FOV at 35% VCR, mainly scenarios B and C. The highest cumulative reductions in the incidence of HPV 6/11/16/18-related disease and deaths were seen in scenario B relative to FOV at 35% VCR at year 100, averting 28,001 cervical cancer (CC) cases, 11,968 non-CC cases (4,753 in females and 7,215 in males) and 15,141 deaths. The greatest projected reductions in health care costs are due to diseases caused by HPV-6/11 infection, driven by GW. The cost savings varied from 88 (scenario A) to 184 million (scenario B) relative to FOV at 35%. The ICER for all scenarios was <0, indicating that under the model assumptions it is cost-saving to implement a GNV-4vHPV in Colombia. In Colombia, a GNV-4vHPV program is a cost-saving strategy in the three scenarios analyzed relative to the current FOV program and result in greater improvement of the public health and economic impact in both women and men. | eng |
dc.format.mimetype | application/pdf | spa |
dc.language.iso | eng | |
dc.publisher | Corporación Universidad de la Costa | spa |
dc.rights | CC0 1.0 Universal | spa |
dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | spa |
dc.source | Value in Health | spa |
dc.subject | Vaccination | eng |
dc.subject | Human Papilloma | eng |
dc.subject | HPV | eng |
dc.subject | Colombia | eng |
dc.title | Estimating the impact of a gender-neutral quadrivalent human papillomavirus vaccination program in all hpv 6/11/16/18 -related diseases in Colombia | eng |
dc.type | Pre-Publicación | spa |
dc.source.url | https://www.valueinhealthjournal.com/article/S1098-3015(20)30677-X/fulltext | spa |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
dc.identifier.doi | https://doi.org/10.1016/j.jval.2020.04.489 | spa |
dc.date.embargoEnd | 2022 | |
dc.identifier.instname | Corporación Universidad de la Costa | spa |
dc.identifier.reponame | REDICUC - Repositorio CUC | spa |
dc.identifier.repourl | https://repositorio.cuc.edu.co/ | spa |
dc.type.coar | http://purl.org/coar/resource_type/c_816b | spa |
dc.type.content | Text | spa |
dc.type.driver | info:eu-repo/semantics/preprint | spa |
dc.type.redcol | http://purl.org/redcol/resource_type/ARTOTR | spa |
dc.type.version | info:eu-repo/semantics/acceptedVersion | spa |
dc.type.coarversion | http://purl.org/coar/version/c_ab4af688f83e57aa | spa |
dc.rights.coar | http://purl.org/coar/access_right/c_abf2 | spa |
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