• español
    • English
    • português (Brasil)
  • English 
    • español
    • English
    • português (Brasil)
  • Login

Repositorio CUC

  • Inicio
  • Colecciones
  • Navegar
    • Autores
    • Títulos
    • Fechas
    • Materias
    • Tipo de Material
  • Biblioteca
  • Información de interés
  • Comunities Comunities
  • Authors Authors
  • Titles Titles
  • Dates Dates
  • Subjects Subjects
  • Resource Type Resource Type
View Item 
  •   DSpace Home
  • Producción científica y académica
  • Artículos científicos
  • View Item
  •   DSpace Home
  • Producción científica y académica
  • Artículos científicos
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Cambiar vista

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsPrint ISSNResource TypeElectronic ISSNProgramThis CollectionBy Issue DateAuthorsTitlesSubjectsPrint ISSNResource TypeElectronic ISSNProgram

My Account

LoginRegister

Statistics

View Usage Statistics

TRF1 as a major contributor for telomeres’ shortening in the context of obesity


Grun Kich, Lucas
Nevton Da Rosa, Teixeira
Mengden Von, Lúcia
De Bastiani, Marco Antônio
Parisi Migliorini, Mariana
Calixto Bortolin, Rafael
Lavandoski, Patrícia
Pierdona, Vinícius
Alves Biscaino, Letícia
Moreira Fonseca, José Cláudio
Mottin Corá, Cláudio
Jones, Marcus Herbert
Klamt, Fábio
Vontobel Padoin, Alexandre
Guma Costa R.Rodrigues, Fátima
Barbé Tuana, Florência María

Artículo de revista

2018-09-24

Free Radical Biology And Medicine

https://doi.org/DOI: 10.1016/j.freeradbiomed.2018.09.039

08915849

AgingBuscar en Repositorio UMECIT
ObesityBuscar en Repositorio UMECIT
Oxidative stressBuscar en Repositorio UMECIT
Shelterin complexBuscar en Repositorio UMECIT
Telomere lengthBuscar en Repositorio UMECIT
TRF1Buscar en Repositorio UMECIT

Obesity is a prevalent multifactorial chronic disorder characterized by metabolic dysregulation. Sustained pro-oxidative mediators trigger harmful consequences that reflect at systemic level and contribute for the establishment of a premature senescent phenotype associated with macromolecular damage (DNA, protein, and lipids). Telomeres are structures that protect chromosome ends and are associated with a six-protein complex called the shelterin complex and subject to regulation. Under pro-oxidant conditions, telomere attrition and the altered expression of the shelterin proteins are central for the establishment of many pathophysiological conditions such as obesity. Thus, considering that individuals with obesity display a systemic oxidative stress profile that may compromise the telomeres length or its regulation, the aim of this study was to investigate telomere homeostasis in patients with obesity and explore broad/systemic associations with the expression of shelterin genes and the plasma redox state. We performed a cross-sectional study in 39 patients with obesity and 27 eutrophic subjects. Telomere length (T/S ratio) and gene expression of shelterin components were performed in peripheral blood mononuclear cells by qPCR.

http://hdl.handle.net/11323/932

  • Artículos científicos [2634]

Descripción: TRF1 As A Major Contributor For Telomeres’.pdf
Título: TRF1 As A Major Contributor For Telomeres’.pdf
Tamaño: 262.3Kb

Unicordoba LogoPDFOpen AccessFLIPLEER EN FLIP

Show full item record

Cita

Cómo citar

Cómo citar

Miniatura

Thumbnail

Gestores Bibliográficos

Exportar a Bibtex

Exportar a RIS

Exportar a Excel

Buscar en google Schoolar

Buscar en microsoft academic

untranslated

Código QR

Envíos recientes

    No hay artículos recientes

HORARIOS DE ATENCIÓN AL USUARIO

LUNES A VIERNES 7:00 a.m a 7:00 p.m

SABADOS: 8:00 a.m a 6:00 p.m

DOMINGOS Y FESTIVOS NO HAY ATENCIÓN


Ubicados en el Bloque 2, Piso 1 y 2

Logo CUC

Contacto

Correo: biblioteca@cuc.edu.co

Telefono: 3362248

Barranquilla, Colombia

Calle 58 # 55-66 Barrio Modelo


Accesos


  • Bases de datos
  • Investigación
  • PQR
  • Catálogo bibliográfico
  • Publish or perish
  • Booklick
  • Libby
Todos los derechos reservados.

Sistema DSPACE - Metabiblioteca | logo