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dc.contributor.authorGrun Kich, Lucasspa
dc.contributor.authorNevton Da Rosa, Teixeiraspa
dc.contributor.authorMengden Von, Lúciaspa
dc.contributor.authorDe Bastiani, Marco Antôniospa
dc.contributor.authorParisi Migliorini, Marianaspa
dc.contributor.authorCalixto Bortolin, Rafaelspa
dc.contributor.authorLavandoski, Patríciaspa
dc.contributor.authorPierdona, Viníciusspa
dc.contributor.authorAlves Biscaino, Letíciaspa
dc.contributor.authorMoreira Fonseca, José Cláudiospa
dc.contributor.authorMottin Corá, Cláudiospa
dc.contributor.authorJones, Marcus Herbertspa
dc.contributor.authorKlamt, Fábiospa
dc.contributor.authorVontobel Padoin, Alexandrespa
dc.contributor.authorGuma Costa R.Rodrigues, Fátimaspa
dc.contributor.authorBarbé Tuana, Florência Maríaspa
dc.date.accessioned2018-11-14T00:44:08Z
dc.date.available2018-11-14T00:44:08Z
dc.date.issued2018-09-24
dc.identifier.issn08915849spa
dc.identifier.urihttp://hdl.handle.net/11323/932spa
dc.description.abstractObesity is a prevalent multifactorial chronic disorder characterized by metabolic dysregulation. Sustained pro-oxidative mediators trigger harmful consequences that reflect at systemic level and contribute for the establishment of a premature senescent phenotype associated with macromolecular damage (DNA, protein, and lipids). Telomeres are structures that protect chromosome ends and are associated with a six-protein complex called the shelterin complex and subject to regulation. Under pro-oxidant conditions, telomere attrition and the altered expression of the shelterin proteins are central for the establishment of many pathophysiological conditions such as obesity. Thus, considering that individuals with obesity display a systemic oxidative stress profile that may compromise the telomeres length or its regulation, the aim of this study was to investigate telomere homeostasis in patients with obesity and explore broad/systemic associations with the expression of shelterin genes and the plasma redox state. We performed a cross-sectional study in 39 patients with obesity and 27 eutrophic subjects. Telomere length (T/S ratio) and gene expression of shelterin components were performed in peripheral blood mononuclear cells by qPCR.spa
dc.language.isoeng
dc.publisherFree Radical Biology And Medicinespa
dc.rightsAtribución – No comercial – Compartir igualspa
dc.subjectAgingeng
dc.subjectObesityeng
dc.subjectOxidative stresseng
dc.subjectShelterin complexeng
dc.subjectTelomere lengtheng
dc.subjectTRF1eng
dc.titleTRF1 as a major contributor for telomeres’ shortening in the context of obesityeng
dc.typeArtículo de revistaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.identifier.doiDOI: 10.1016/j.freeradbiomed.2018.09.039spa
dc.identifier.instnameCorporación Universidad de la Costaspa
dc.identifier.reponameREDICUC - Repositorio CUCspa
dc.identifier.repourlhttps://repositorio.cuc.edu.co/spa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa


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