Mostrar el registro sencillo del ítem

dc.contributor.authorSantos Sousa, Rejanespa
dc.contributor.authorSantos Sousa, Carolinespa
dc.contributor.authorCosta Oliveira, Francisco Leonardospa
dc.contributor.authorFirmino, Paulo Ricardospa
dc.contributor.authorFreitas Sousa, Isadora Karolinaspa
dc.contributor.authorVeras Paula, Valeriaspa
dc.contributor.authorMercado Caruso, Nohora Nubiaspa
dc.contributor.authorLippi Ortolani, Enricospa
dc.contributor.authorMinervino, Antoniospa
dc.contributor.authorBarrêto-Júnior, Raimundo Alvesspa
dc.date.accessioned2022-08-05T22:11:26Z
dc.date.available2022-08-05T22:11:26Z
dc.date.issued2022-05-11
dc.identifier.citationSousa, R.S.; Sousa, C.S.; Oliveira, F.L.C.; Firmino, P.R.; Sousa, I.K.F.; Paula, V.V.; Caruso, N.M.; Ortolani, E.L.; Minervino, A.H.H.; Barrêto-Júnior, R.A. Impact of Acute Blood Loss on Clinical, Hematological, Biochemical, and Oxidative Stress Variables in Sheep. Vet. Sci. 2022, 9, 229. https:// doi.org/10.3390/vetsci9050229spa
dc.identifier.urihttps://hdl.handle.net/11323/9435spa
dc.description.abstractBlood loss in sheep can have different causes and may result in anemia. We aimed to evaluate the clinical, hematological, and biochemical alterations and the oxidative stress generated by acute blood loss. Eighteen healthy sheep underwent phlebotomy to remove 40% of the blood volume and were evaluated clinically and by laboratory tests for clinical, biochemical, and blood gas variables and to assess oxidative stress before induction (T0), 30 min (T30 min), and 6 (T6 h), 12 (T12 h), and 24 h (T24 h) after blood loss. The sheep showed tachycardia from T30 min until T24 h, reduction in the hematocrit, number of erythrocytes, and hemoglobin concentration, with lower values at T24 h and increase in the number of leukocytes from T12 h on. There was a reduction in blood pH and oxygen pressure at T30 min, increased lactate concentration and reduced blood bicarbonate at this time. There was an increase in urea concentration from T6 h until the end of the study, with no change in creatinine levels. The animals did not show changes in the concentration of malonaldehyde, and in the activity of the enzymes superoxide dismutase, glutathione peroxidase, and catalase, but there was a reduction in the concentration of reduced glutathione at T24 h. The acute loss of 40% of blood volume is capable of promoting relevant clinical, hematological, blood gas, and biochemical alterations, and contributed to the appearance of oxidative stress with reduced glutathione concentration, suggesting that this process generated free radicals in sufficient quantity to diminish the action of antioxidants.eng
dc.format.extent9 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)spa
dc.rightsAtribución 4.0 Internacional (CC BY 4.0)spa
dc.rights© 2022 by the authors. Licensee MDPI, Basel, Switzerland.spa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/spa
dc.titleImpact of acute blood loss on clinical, hematological, biochemical, and oxidative stress variables in sheepeng
dc.typeArtículo de revistaspa
dc.identifier.urlhttps:// doi.org/10.3390/vetsci9050229spa
dc.source.urlhttps://www.mdpi.com/2306-7381/9/5/229spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.identifier.doi10.3390/vetsci9050229spa
dc.identifier.eissn2306-7381spa
dc.identifier.instnameCorporación Universidad de la Costaspa
dc.identifier.reponameREDICUC - Repositorio CUCspa
dc.identifier.repourlhttps://repositorio.cuc.edu.co/spa
dc.publisher.placeSwitzerlandspa
dc.relation.ispartofjournalVeterinary Sciencesspa
dc.relation.references1. de Azambuja Ribeiro, E.L.; González-García, E. Indigenous Sheep Breeds in Brazil: Potential Role for Contributing to the Sustainability of Production Systems. Trop. Anim. Health Prod. 2016, 48, 1305–1313. [CrossRef] [PubMed]spa
dc.relation.references2. Raineri, C.; Nunes, B.C.P.; Gameiro, A.H. Technological Characterization of Sheep Production Systems in Brazil. Anim. Sci. J. 2015, 86, 476–485. [CrossRef] [PubMed]spa
dc.relation.references3. Debortoli, E.C.; Monteiro, A.L.G.; Gameiro, A.H.; Saraiva, L.C.V.F. Meat Sheep Farming Systems According to Economic and Productive Indicators: A Case Study in Southern Brazil. Rev. Bras. Zootec. 2021, 50, 1–12. [CrossRef]spa
dc.relation.references4. IBGE (Instituto Brasileiro de Geografía e Estatística). Produção Pecuária Municipal; IBGE: Rio de Janeiro, Brazil, 2020. Available online: https://sidra.ibge.gov.br/tabela/3939 (accessed on 15 January 2021).spa
dc.relation.references5. Argolo, E.P.; Firmino, P.R.; Soares, J.O.; Nunes, T.L.; Abrantes, M.R.; Sousa, R.S.; Oliveira, F.L.C.; Paula, V.V.; Ortolani, E.L.; Minervino, A.H.H.; et al. Clinical Responses to Acute Blood Loss in Goats. Semin. Cienc. Agrar. 2018, 39, 583–592. [CrossRef]spa
dc.relation.references6. Thrall, M.A.; Fagliari, J.J.; Thiesen, R.; Barros Sobrinho, A. Hematologia e Bioquímica Clínica Veterinária; Roca: Barcelona, Spain, 2014; ISBN 8541204405.spa
dc.relation.references7. Abdalla, S.E.; Abdelatif, A.M.; Omer, S.A. Thermoregulation and Haematological Responses to Induced Acute Haemorrhage in Adult Nubian Goats. J. Appl. Life Sci. Int. 2019, 21, 1–12. [CrossRef]spa
dc.relation.references8. Abdalla, S.E.; Abdelatif, A.M. Effects of Haemorrhage on Thermoregulation, Heart Rate and Blood Constituents in Goats (Capra Hircus). Pak. J. Biol. Sci. 2008, 11, 1194–1203. [CrossRef]spa
dc.relation.references9. Dorneles, T.E.A.; Junior, J.D.C.; Almeida, R.M.; Neto, A.R.T. Biochemical and Hematologic Changes in Whole Blood from Brazilian Horses Stored in Citrate–Phosphate–Dextrose–Adenine Pouches for up to 28 Days. Vet. Clin. Pathol. 2021, 50, 221–226. [CrossRef]spa
dc.relation.references10. Grune, T.; Sommerburg, O.; Siems, W.G. Oxidative Stress in Anemia. Clin. Nephrol. 2000, 53, 18–22.spa
dc.relation.references11. Sarada, S.K.S.; Dipti, P.; Anju, B.; Pauline, T.; Kain, A.K.; Sairam, M.; Sharma, S.K.; Ilavazhagan, G.; Kumar, D.; Selvamurthy, W. Antioxidant Effect of Beta-Carotene on Hypoxia Induced Oxidative Stress in Male Albino Rats. J. Ethnopharmacol. 2002, 79, 149–153. [CrossRef]spa
dc.relation.references12. Chiumiento, L.; Bruschi, F. Enzymatic Antioxidant Systems in Helminth Parasites. Parasitol. Res. 2009, 105, 593–603. [CrossRef]spa
dc.relation.references13. Baptistiolli, L.; Narciso, L.G.; de Almeida, B.F.M.; Bosco, A.M.; de Souza, J.C.; Torrecilha, R.B.P.; Pereira, P.P.; Figueiredo, R.N.; Garcia, J.F.; Kaneto, C.N.; et al. Systemic Oxidative Stress in Suffolk and Santa Ines Sheep Experimentally Infected with Haemonchus Contortus. Acta Parasitol. 2018, 63, 504–514. [CrossRef] [PubMed]spa
dc.relation.references14. Esmaeilnejad, B.; Tavassoli, M.; Asri-Rezaei, S.; Dalir-Naghadeh, B.; Malekinejad, H.; Jalilzadeh-Amin, G.; Arjmand, J.; Golabi, M.; Hajipour, N. Evaluation of Antioxidant Status, Oxidative Stress and Serum Trace Mineral Levels Associated with Babesia Ovis Parasitemia in Sheep. Vet. Parasitol. 2014, 205, 38–45. [CrossRef] [PubMed]spa
dc.relation.references15. Sousa, R.S.; Minervino, A.H.H.; Oliveira, F.L.C.; Araújo, C.A.S.C.; Rodrigues, F.A.M.L.; Zaminhan, J.L.R.; Vale, R.G.; Tavares, M.D.; Mori, C.S.; de Paula, V.V.; et al. Impact of Blood Storage Duration on Hematologic, Blood Gas, Biochemical, and Oxidative Stress Variables in Sheep Undergoing Allogeneic Blood Transfusions. Vet. Clin. Pathol. 2020, 49, 545–556. [CrossRef] [PubMed]spa
dc.relation.references16. Nunes Neto, O.G.; Ricarte, S.A.; Sousa, R.S.; Portela, J.M.; Morini, A.C.; Neves, K.A.L.; Batista, H.R.; Oliveira, F.L.C.; Ortolani, E.L.; Barreto Junior, R.A.; et al. Hematological Changes in Buffalo (Bubalus Bubalis) Whole Blood Stored in CPDA-1 or CPD/SAG-M Plastic Bags. Buffalo Bull. 2018, 37, 403–410.spa
dc.relation.references17. Barros, I.O.; Sousa, R.S.; Tavares, M.D.; Rêgo, R.O.; Firmino, P.R.; Souza, F.J.A.; Abrantes, M.R.; Minervino, A.H.H.; Araújo, C.A.S.C.; Ortolani, E.L.; et al. Assessment of Donkey (Equus asinus africanus) Whole Blood Stored in CPDA-1 and CPD/SAG-M Blood Bags. Biology 2021, 10, 133. [CrossRef]spa
dc.relation.references18. Notomi, M.K.; de Gopegui, R.R.; Escodro, P.B. Haematologic Effects of Leukoreduction on Canine Whole Blood Post-Filtration and Post-Storage. Comp. Clin. Pathol. 2016, 25, 145–149. [CrossRef]spa
dc.relation.references19. Cummings, K.A.; Abelson, A.L.; Rozanski, E.A.; Sharp, C.R. The Effect of Storage on Ammonia, Cytokine, and Chemokine Concentrations in Feline Whole Blood. J. Vet. Emerg. Crit. Care 2016, 26, 639–645. [CrossRef]spa
dc.relation.references20. Pereira, E.S.; Lima, F.W.R.; Marcondes, M.I.; Rodrigues, J.P.P.; Campos, A.C.N.; Silva, L.P.; Bezerra, L.R.; Pereira, M.W.F.; Oliveira, R.L. Energy and Protein Requirements of Santa Ines Lambs, a Breed of Hair Sheep. Animal 2017, 11, 2165–2174. [CrossRef]spa
dc.relation.references21. Radostits, O.M.; Gay, C.C.; Hinchcliff, K.W.; Constable, P.D. Veterinary Medicine: A Textbook of the Diseases of Cattle, Sheep, Pigs, Goats, and Horses, 10th ed.; Saunders Elsevier: Philadelphia, PA, USA, 2007; ISBN 0702027774.spa
dc.relation.references22. Vinholte, B.P.; Sousa, R.d.S.; Assis, F.F.V.; Nunes Neto, O.G.; Portela, J.M.; Pinto, G.A.S.; Ortolani, E.L.; Benesi, F.J.; Barrêto Júnior, R.A.; Minervino, A.H.H. The Effects of Pre-Storage Leukoreduction on the Conservation of Bovine Whole Blood in Plastic Bags. Biology 2020, 9, 444. [CrossRef]spa
dc.relation.references23. Ortolani, E.L.; Maruta, C.A.; Barrêto Junior, R.A.; Mori, C.S.; Antonelli, A.C.; Sucupira, M.C.A.; Minervino, A.H.H. Metabolic Profile of Steers Subjected to Normal Feeding, Fasting, and Re-Feeding Conditions. Vet. Sci. 2020, 7, 95. [CrossRef]spa
dc.relation.references24. Esterbauer, H.; Cheeseman, K.H. Determination of Aldehydic Lipid Peroxidation Products: Malonaldehyde and 4-Hydroxynonenal. Methods Enzymol. 1990, 186, 407–421. [PubMed]spa
dc.relation.references25. Beutler, E.; Duron, O.; Kelly, B.M. Improved Method for the Determination of Blood Glutathione. J. Lab. Clin. Med. 1963, 61, 882–888. [PubMed]spa
dc.relation.references26. Aebi, H. Catalase in Vitro. Methods Enzymol. 1984, 105, 121–126. [PubMed]spa
dc.relation.references27. Bordin, A.I.; Oliveira, H.P.; Freitas, C.F.; Verçosa, D.; Marval, C.A.; Fonseca, M.R.; Pagliosa, G.; Souza, M.V.; Alves, G.E.S. Effects of 7,5% Hypertonic Saline in 5% Glucose on Serum Levels of Sodium, Chloride and Potassium in Induced Hypovolemic Horses. Arq. Bras. Med. Vet. Zootec. 2007, 59, 621–626. [CrossRef]spa
dc.relation.references28. Marson, F.; Pereira, G.A., Jr.; Filho, A.P.; Basile-Filho, A. A Síndrome Do Choque Circulatório. Medicina 1998, 31, 369–379. [CrossRef]spa
dc.relation.references29. Scully, C.G.; Daluwatte, C.; Marques, N.R.; Khan, M.; Salter, M.; Wolf, J.; Nelson, C.; Salsbury, J.; Enkhbaatar, P.; Kinsky, M.; et al. Effect of Hemorrhage Rate on Early Hemodynamic Responses in Conscious Sheep. Physiol. Rep. 2016, 4, e12739. [CrossRef]spa
dc.relation.references30. Richard, P. Dutton Pathophysiology of Traumatic Shock. In Massive Transfusion and Control of Hemorrhage in the Trauma Patient; Smith, C.E., Rosenberg, A.D., Grande, C.M., Eds.; International Trauma Anesthesia and Critical Care Society: Baltimore, MD, USA, 2003; pp. 5–7.spa
dc.relation.references31. Klein, B.G. Cunnigham’s Textbook of Veterinary Physiology; Elsevier Health Sciences: Philadelphia, PA, USA, 2013; ISBN 9780323266314.spa
dc.relation.references32. Mohamed Abdelatif, A.; Abdalla, S.E.; Abdelatif, A.M. Physiological Responses of Goats (Capra hircus) to Haemorrhage as Influenced by Splenectomy. J. Sci. Res. 2010, 5, 76–87.spa
dc.relation.references33. Weiss, D.J.; Wardrop, K.J.; Weiss, D.J. Schalm’s Veterinary Hematology; Wiley: New York, NY, USA, 2011; ISBN 047096183X.spa
dc.relation.references34. Roth, J.A.; Kaeberle, M.L. Effect of Glucocorticoids on the Bovine Immune System. J. Am. Vet. Med. Assoc. 1982, 180, 894–901.spa
dc.relation.references35. Yang, E.V.; Glaser, R. Stress-Induced Immunomodulation and the Implications for Health. Int. Immunopharmacol. 2002, 2, 315–324. [CrossRef]spa
dc.relation.references36. Sousa, R.S.; Chaves, D.F.; Barrêto-Júnior, R.A.; Sousa, I.K.F.; Soares, H.S.; Barros, I.O.; Minervino, A.H.H.; Ortolani, E.L. Clinical, Haematological and Biochemical Responses of Sheep Undergoing Autologous Blood Transfusion. BMC Vet. Res. 2012, 8, 61. [CrossRef]spa
dc.relation.references37. Fonteque, J.H. Estresse Oxidativo e Lipoperoxidação Devido à Anemia Induzida Por Perda Aguda de Sangue Em Ovinos; Universidade Estadual Paulista (UNESP): São Paulo, Brazil, 2005.spa
dc.relation.references38. Kaneko, J.J.; Harvey, J.J.; Bruss, M.L. Clinical Biochemistry of Domestic Animals; Elsevier: Amsterdam, The Netherlands; Academic Press: Cambridge, MA, USA, 2008; ISBN 9780123704917.spa
dc.relation.references39. Wintour, E.M.; Moritz, K.M.; Potocnik, S.J. Cardiovascular, Hormonal, and Metabolic Responses to Severe Prolonged Hemorrhage in Adult Sheep. Am. J. Vet. Res. 1995, 56, 1232–1240. [PubMed]spa
dc.relation.references40. Costagliola, C.; Romano, L.; Sorice, L.; Di Benedetto, A. Anemia and Chronic Renal Failure: The Possible Role of the Oxidative State of Glutathione. Nephron 1989, 52, 11–14. [CrossRef] [PubMed]spa
dc.relation.references41. Ludat, K.; Sommerburg, O.; Grune, T.; Siems, W.G.; Riedel, E.; Hampl, H. Oxidation Parameters in Complete Correction of Renal Anemia. Clin. Nephrol. 2000, 53, S30–S35.spa
dc.relation.references42. Nanev, V.; Gabrashanska, M.; Vladov, I. Impact of Haemonchus Contortus (Nematoda) Infection on the Oxidant/Antioxidant Status in Lambs. Ecologica 2012, 19, 426–429.spa
dc.relation.references43. Dominguez, C.; Ruiz, E.; Gussinye, M.; Carrascosa, A. Oxidative Stress at Onset and in Early Stages of Type 1 Diabetes in Children and Adolescents. Diabetes Care 1998, 21, 1736–1742. [CrossRef] [PubMed]spa
dc.relation.references44. Rashid, S.; Irshadullah, M. Evaluation of Antioxidant and Oxidant Status of Goats (Capra aegagrus hircus) Naturally Infected with Haemonchus Contortus. J. Helminthol. 2020, 94, E36. [CrossRef] [PubMed]spa
dc.subject.proposalAnemiaeng
dc.subject.proposalOvineeng
dc.subject.proposalSuperoxide dismutaseeng
dc.subject.proposalGlutathione peroxidaseeng
dc.subject.proposalCatalaseeng
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.relation.citationendpage9spa
dc.relation.citationstartpage1spa
dc.relation.citationissue5spa
dc.relation.citationvolume9spa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa


Ficheros en el ítem

Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

  • Artículos científicos [3120]
    Artículos de investigación publicados por miembros de la comunidad universitaria.

Mostrar el registro sencillo del ítem

Atribución 4.0 Internacional (CC BY 4.0)
Excepto si se señala otra cosa, la licencia del ítem se describe como Atribución 4.0 Internacional (CC BY 4.0)