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Universidad de la Costa, CUC. Calle 58 # 55 - 66. Barranquilla, Colombia. 336 22 00. repositorioredicuc@cuc.edu.co. Corporación Universidad de la Costa.

Optical Properties And Antiangiogenic Activity Of A Chalcone Derivate

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Optical Properties And Antiangiogenic (280.6Kb)
Date
2018-06-26
Author
Lemes, Susy Ricardo
Júnior, Luizmar Adriano
Da Silva Manoel, Diego
De Sousa Montes, Maria Alice
Fonseca Rodriguez, Ruben Dario
Lima Silva, Rosa S
Noda Pérez, Caridad
De Melo Reis, Paulo Roberto
Cardoso Gomes, Cléver
De Paula Silveira Lacerda, Elisângela
Souza Rodrigues, Marcio Adriano
Mendonça, Cleber Renato
Gonçalves, Pablo José
De Boni, Leonardo
Da Fonseca, Tertius Lima
Da Silva Júnior, Nelson Jorge
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URI: http://hdl.handle.net/11323/978
Citar con DOI: https://doi.org/10.1016/j.saa.2018.06.099

Abstract

Chalcones and their derivatives exhibit numerous pharmacological activities such as antibacterial, antifungal, cytotoxic, antinociceptive and anti-inflammatory. Recently, they have been assessed aiming for novel application in nonlinear optics and in the treatment of immune diseases and cancers. In this study, we investigate the optical properties of synthetic chalcona 1E,4E-1-(4-chlorophenyl)-5-(2,6,6-trimethylcyclohexen-1-yl)penta-1,4-dien-3-one (CAB7β) and its antiangiogenic potential using the chorioallantoic membrane (CAM) with the S180 sarcoma cell line. Experimental and theoretical results show intense absorption in the UVA-UVC region, which is associated with a π → π* transition with intramolecular charge transfer from the trimethyl-cyclohexen-1-yl ring to the chlorophenyl ring. Quantum chemical calculations of the first hyperpolarizability, accounting for both solvent and frequency dispersion effects, are in very good concordance with hyper-Rayleigh scattering measurements. In addition, two-photon absorption allowed band centered at 650 nm was observed. Concerning antiangiogenic activity, CAB7β causes a significant reduction in the total number, junctions, length and caliber of blood vessels stimulated by S180 cells reducing the presence of blood vessels, inflammatory cells and others elements related to angiogenic process. It is found that CAB7β is a versatile compound and a promising candidate for linear and nonlinear optical applications, in therapy against sarcoma and phototherapy.
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  • Calle 58 # 55 - 66. Barranquilla, Colombia

  • 336 22 00

  • repositorioredicuc@cuc.edu.co

Corporación Universidad de la Costa CUC, Personería Jurídica con Resolución No. 352 del 23 de abril de 1971 y reconocida como Universidad mediante resolución 3235 del 28 de marzo de 2012 expedida por el MEN. Institución de Educación Superior sujeta a inspección y vigilancia por el Ministerio de Educación Nacional.

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