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dc.creatorLemes, Susy Ricardo
dc.creatorJúnior, Luizmar Adriano
dc.creatorDa Silva Manoel, Diego
dc.creatorDe Sousa Montes, Maria Alice
dc.creatorFonseca Rodriguez, Ruben Dario
dc.creatorLima Silva, Rosa S
dc.creatorNoda Pérez, Caridad
dc.creatorDe Melo Reis, Paulo Roberto
dc.creatorCardoso Gomes, Cléver
dc.creatorDe Paula Silveira Lacerda, Elisângela
dc.creatorSouza Rodrigues, Marcio Adriano
dc.creatorMendonça, Cleber Renato
dc.creatorGonçalves, Pablo José
dc.creatorDe Boni, Leonardo
dc.creatorDa Fonseca, Tertius Lima
dc.creatorDa Silva Júnior, Nelson Jorge
dc.date.accessioned2018-11-14T18:43:06Z
dc.date.available2018-11-14T18:43:06Z
dc.date.issued2018-06-26
dc.identifier.issn13861425
dc.identifier.urihttp://hdl.handle.net/11323/978
dc.description.abstractChalcones and their derivatives exhibit numerous pharmacological activities such as antibacterial, antifungal, cytotoxic, antinociceptive and anti-inflammatory. Recently, they have been assessed aiming for novel application in nonlinear optics and in the treatment of immune diseases and cancers. In this study, we investigate the optical properties of synthetic chalcona 1E,4E-1-(4-chlorophenyl)-5-(2,6,6-trimethylcyclohexen-1-yl)penta-1,4-dien-3-one (CAB7β) and its antiangiogenic potential using the chorioallantoic membrane (CAM) with the S180 sarcoma cell line. Experimental and theoretical results show intense absorption in the UVA-UVC region, which is associated with a π → π* transition with intramolecular charge transfer from the trimethyl-cyclohexen-1-yl ring to the chlorophenyl ring. Quantum chemical calculations of the first hyperpolarizability, accounting for both solvent and frequency dispersion effects, are in very good concordance with hyper-Rayleigh scattering measurements. In addition, two-photon absorption allowed band centered at 650 nm was observed. Concerning antiangiogenic activity, CAB7β causes a significant reduction in the total number, junctions, length and caliber of blood vessels stimulated by S180 cells reducing the presence of blood vessels, inflammatory cells and others elements related to angiogenic process. It is found that CAB7β is a versatile compound and a promising candidate for linear and nonlinear optical applications, in therapy against sarcoma and phototherapy.es_CO
dc.language.isoengen_US
dc.publisherSpectrochimica Acta - Part A: Molecular And Biomolecular Spectroscopyen_US
dc.relation.ispartofDOI: 10.1016/j.saa.2018.06.099en_US
dc.rightsAtribución – No comercial – Compartir igualen_US
dc.subjectAntiangiogic Activityen_US
dc.subjectChalconaen_US
dc.subjectOptical Propertiesen_US
dc.subjectSarcomaen_US
dc.titleOptical Properties And Antiangiogenic Activity Of A Chalcone Derivateen_US
dc.typearticleen_US


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