• Index page
  • Información de interés
  • Login
  • Communities & Collections
  • Language
    Englishespañolportuguês (Brasil)
View Item 
  •   Redicuc Home
  • Producción científica y académica
  • Artículos científicos
  • View Item
  •   Redicuc Home
  • Producción científica y académica
  • Artículos científicos
  • View Item
Universidad de la Costa, CUC. Calle 58 # 55 - 66. Barranquilla, Colombia. 336 22 00. repositorioredicuc@cuc.edu.co. Corporación Universidad de la Costa.

Effects Of Methylmercury And Retinol Palmitate Co-Administration In Rats During Pregnancy And Breastfeeding: Metabolic And Redox Parameters In Dams And Their Offspring

Thumbnail
View/Open
Effects Of Methylmercury And Retinol (179.6Kb)
Date
2018-06-29
Author
Espitia Pérez, Pedro
Albino Marin, Suelen
Da Rosa, Helen Tais
Silveira, Alexandre Kleber
Espitia Pérez, Lyda
Brango, Hugo
Moraes Pompéu, Diogo
Hermann Silva, Paolla Rissi
Mingori Rodrigues, Moara
Barreto, Fabiano
Kunzler, Alice
Gelain, D. P.
Schnorr, Carlos Eduardo
Moreira Fonseca, José Cláudio
Metadata
Show full item record
BASE GoogleScholar
Compartir:


Impacto

URI: http://hdl.handle.net/11323/990
Citar con DOI: DOI: 10.1016/j.ecoenv.2018.06.093

Abstract

Ubiquitous low-dose methylmercury (MeHg) exposure through an increased fish consumption represents a global public health problem, especially among pregnant women. A plethora of micronutrients presented in fish affects MeHg uptake/distribution, but limited data is available. Vitamin A (VitA), another fish micronutrient is used in nutritional supplementation, especially during pregnancy. However, there is no information about the health effects arising from their combined exposure. Therefore, the present study aimed to examine the effects of both MeHg and retinyl palmitate administered on pregnant and lactating rats in metabolic and redox parameters from dams and their offspring. Thirty Wistar female rats were orally supplemented with MeHg (0,5 mg/kg/day) and retinyl palmitate (7500 µg RAE/kg/day) via gavage, either individually or in combination from the gestational day 0 to weaning. For dams (150 days old) and their offspring (31 days old), glycogen accumulation (hepatic and cardiac) and retinoid contents (plasma and liver) were analyzed. Hg deposition in liver tissue was quantified. Redox parameters (liver, kidney, and heart) were evaluated for both animals. Cytogenetic damage was analyzed with micronucleus test. Our results showed no general toxic or metabolic alterations in dams and their offspring by MeHg-VitA co-administration during pregnancy and lactation. However, increased lipoperoxidation in maternal liver and a disrupted pro-oxidant response in the heart of male pups was encountered, with apparently no particular effects in the antioxidant response in female offspring. GST activity in dam kidney was altered leading to possible redox disruption of this tissue with no alterations in offspring. Finally, the genomic damage was exacerbated in both male and female pups. In conclusion, low-dose MeHg exposure and retinyl palmitate supplementation during gestation and lactation produced a potentiated pro-oxidant effect, which was tissue-specific. Although this is a pre-clinical approach, we recommend precaution for pregnant women regarding food consumption, and we encourage more epidemiological studies to assess possible modulations effects of MeHg-VitA co-administration at safe or inadvertently used doses in humans, which may be related to specific pathologies in mothers and their children.
Collections
  • Artículos científicos

Browse

All of RedicucCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Compartir en

Universidad de la Costa, CUC

  • Calle 58 # 55 - 66. Barranquilla, Colombia

  • 336 22 00

  • repositorioredicuc@cuc.edu.co

Corporación Universidad de la Costa CUC, Personería Jurídica con Resolución No. 352 del 23 de abril de 1971 y reconocida como Universidad mediante resolución 3235 del 28 de marzo de 2012 expedida por el MEN. Institución de Educación Superior sujeta a inspección y vigilancia por el Ministerio de Educación Nacional.

Enlaces institucionales:

  • Universidad de la Costa
  • Biblioteca
  • Catálogo bibliográfico
  • Recuperador Primo

Universidad de la Costa CUC.
Politica de Protección de Datos.