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dc.creatorEspitia Pérez, Pedro
dc.creatorAlbino Marin, Suelen
dc.creatorDa Rosa, Helen Tais
dc.creatorSilveira, Alexandre Kleber
dc.creatorEspitia Pérez, Lyda
dc.creatorBrango, Hugo
dc.creatorMoraes Pompéu, Diogo
dc.creatorHermann Silva, Paolla Rissi
dc.creatorMingori Rodrigues, Moara
dc.creatorBarreto, Fabiano
dc.creatorKunzler, Alice
dc.creatorGelain, D. P.
dc.creatorSchnorr, Carlos Eduardo
dc.creatorMoreira Fonseca, José Cláudio
dc.date.accessioned2018-11-14T19:43:48Z
dc.date.available2018-11-14T19:43:48Z
dc.date.issued2018-06-29
dc.identifier.issn01476513
dc.identifier.urihttp://hdl.handle.net/11323/990
dc.description.abstractUbiquitous low-dose methylmercury (MeHg) exposure through an increased fish consumption represents a global public health problem, especially among pregnant women. A plethora of micronutrients presented in fish affects MeHg uptake/distribution, but limited data is available. Vitamin A (VitA), another fish micronutrient is used in nutritional supplementation, especially during pregnancy. However, there is no information about the health effects arising from their combined exposure. Therefore, the present study aimed to examine the effects of both MeHg and retinyl palmitate administered on pregnant and lactating rats in metabolic and redox parameters from dams and their offspring. Thirty Wistar female rats were orally supplemented with MeHg (0,5 mg/kg/day) and retinyl palmitate (7500 µg RAE/kg/day) via gavage, either individually or in combination from the gestational day 0 to weaning. For dams (150 days old) and their offspring (31 days old), glycogen accumulation (hepatic and cardiac) and retinoid contents (plasma and liver) were analyzed. Hg deposition in liver tissue was quantified. Redox parameters (liver, kidney, and heart) were evaluated for both animals. Cytogenetic damage was analyzed with micronucleus test. Our results showed no general toxic or metabolic alterations in dams and their offspring by MeHg-VitA co-administration during pregnancy and lactation. However, increased lipoperoxidation in maternal liver and a disrupted pro-oxidant response in the heart of male pups was encountered, with apparently no particular effects in the antioxidant response in female offspring. GST activity in dam kidney was altered leading to possible redox disruption of this tissue with no alterations in offspring. Finally, the genomic damage was exacerbated in both male and female pups. In conclusion, low-dose MeHg exposure and retinyl palmitate supplementation during gestation and lactation produced a potentiated pro-oxidant effect, which was tissue-specific. Although this is a pre-clinical approach, we recommend precaution for pregnant women regarding food consumption, and we encourage more epidemiological studies to assess possible modulations effects of MeHg-VitA co-administration at safe or inadvertently used doses in humans, which may be related to specific pathologies in mothers and their children.es_CO
dc.language.isoengen_US
dc.publisherEcotoxicology And Environmental Safetyen_US
dc.relation.ispartofDOI: 10.1016/j.ecoenv.2018.06.093en_US
dc.rightsAtribución – No comercial – Compartir igualen_US
dc.subjectCo-Exposureen_US
dc.subjectMethylmercuryen_US
dc.subjectOxidative Stressen_US
dc.subjectPregnancyen_US
dc.subjectVitamin Aen_US
dc.titleEffects Of Methylmercury And Retinol Palmitate Co-Administration In Rats During Pregnancy And Breastfeeding: Metabolic And Redox Parameters In Dams And Their Offspringen_US
dc.typeArticleen_US


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